Evidence map›Paper›PMID 41806836›Full record

ArticleCell reports. Medicine2026

TRPM3 mediates spontaneous pain and mechanical allodynia in a mouse model of chronic orofacial neuropathy.

Kristof Deseure, Ilhem Dallali, Silvia Pinto, Katrien Luyten, Andrei Segal, Nele Van Ranst, Robbe Roelens, Sean Corbett, Stuart Murray, Eleonora Persoons and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports. Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Kristof DeseureLaboratory of Algology, Antwerp Surgical Training, Anatomy and Research Centre, University of Antwerp, Antwerp, Belgium; Multidisciplinary Pain Center, Antwerp University Hospital, Antwerp, Belgium.
Ilhem DallaliLaboratory of Ion Channel Research (LICR), VIB-KUL Leuven Center for Neuroscience, Leuven, Belgium; Department of Molecular and Cellular Biology, KU Leuven, Leuven, Belgium.
Silvia PintoLaboratory of Ion Channel Research (LICR), VIB-KUL Leuven Center for Neuroscience, Leuven, Belgium; Department of Molecular and Cellular Biology, KU Leuven, Leuven, Belgium; Behavioral Unit, VIB-KUL Leuven Center for Neuroscience, Leuven, Belgium.
Katrien LuytenImplantation, Placentation, Pregnancy and Endometriosis (POPPYe) Research Group, Department of Development and Regeneration, KU Leuven, Leuven, Belgium.
Andrei SegalLaboratory of Ion Channel Research (LICR), VIB-KUL Leuven Center for Neuroscience, Leuven, Belgium; Department of Molecular and Cellular Biology, KU Leuven, Leuven, Belgium.
Nele Van RanstLaboratory of Ion Channel Research (LICR), VIB-KUL Leuven Center for Neuroscience, Leuven, Belgium; Department of Molecular and Cellular Biology, KU Leuven, Leuven, Belgium.
Robbe RoelensLaboratory of Ion Channel Research (LICR), VIB-KUL Leuven Center for Neuroscience, Leuven, Belgium; Department of Molecular and Cellular Biology, KU Leuven, Leuven, Belgium; Implantation, Placentation, Pregnancy and Endometriosis (POPPYe) Research Group, Department of Development and Regeneration, KU Leuven, Leuven, Belgium.
Sean CorbettBiohaven Pharmaceuticals, New Haven, CT, USA.
Stuart MurrayBiohaven Pharmaceuticals, New Haven, CT, USA.
Eleonora PersoonsLaboratory of Ion Channel Research (LICR), VIB-KUL Leuven Center for Neuroscience, Leuven, Belgium; Department of Molecular and Cellular Biology, KU Leuven, Leuven, Belgium; Implantation, Placentation, Pregnancy and Endometriosis (POPPYe) Research Group, Department of Development and Regeneration, KU Leuven, Leuven, Belgium.
Guy HansLaboratory of Algology, Antwerp Surgical Training, Anatomy and Research Centre, University of Antwerp, Antwerp, Belgium; Multidisciplinary Pain Center, Antwerp University Hospital, Antwerp, Belgium.
Joris VriensLaboratory of Ion Channel Research (LICR), VIB-KUL Leuven Center for Neuroscience, Leuven, Belgium; Implantation, Placentation, Pregnancy and Endometriosis (POPPYe) Research Group, Department of Development and Regeneration, KU Leuven, Leuven, Belgium.
Thomas VoetsLaboratory of Ion Channel Research (LICR), VIB-KUL Leuven Center for Neuroscience, Leuven, Belgium; Department of Molecular and Cellular Biology, KU Leuven, Leuven, Belgium. Electronic address: thomas.voets@kuleuven.be.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Trigeminal nerve injury can lead to chronic and difficult-to-treat orofacial neuropathic pain. Here, we uncover a key role for the cation channel TRPM3 in the chronic constriction injury of the infraorbital nerve (IoN-CCI) mouse model of trigeminal neuropathic pain. Wild-type (WT) mice develop spontaneous pain and mechanical allodynia for up to 6 weeks following IoN-CCI, whereas Trpm3

Indexed as

Facial PainHyperalgesiaNeuralgiaTRPM Cation ChannelsAnimalsDisease Models, AnimalMaleMiceMice, Inbred C57BLMice, KnockoutTrigeminal GanglionTrigeminal Nerve InjuriesTRPM3 protein, mouseTRPM Cation Channelsneuropathic paintrigeminal neuronTRP channelsTRPM3

Identifiers

PMID41806836
PMCPMC13006437

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.