ArticleJournal of veterinary internal medicine2026
Calciprotein particles in cats with naturally occurring chronic kidney disease.
Article in Journal of veterinary internal medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
backgroundCalciprotein particles (CPP) are nanoparticles that play an important role in the pathogenesis of chronic kidney disease-mineral and bone disorder (CKD-MBD). HYPOTHESIS/
objectivesIdentification of plasma CPP and preliminary exploration of the relationships among CPP concentrations, calcification propensity (T50), and CKD-MBD variables in cats with azotemic CKD. ANIMALS: Cats with azotemic CKD (n = 52) stabilized on a phosphate-restricted diet (PRD).
methodsTotal CPP (T-CPP), low-density CPP (L-CPP), and high-density CPP (H-CPP) were measured in heparinized plasma using a fluorescent bisphosphonate (OsteoSense) after gel filtration. Standardized linear regression models evaluated associations among CPP, T50, and CKD-MBD variables. Generalized estimating equations compared preprandial and postprandial CPP concentrations. Calciprotein particle changes (ΔCPP) between visits were compared between cats with different ionized calcium (iCa) trajectories using independent samples t-test or Mann-Whitney U tests.
resultsFibroblast growth factor-23 (standardized coefficient [sβ], 0.35; P = .04) and parathyroid hormones (sβ, -0.34; P = .042) were significantly associated with preprandial T-CPP concentrations in cats fed a PRD, whereas phosphate was significantly associated with postprandial T-CPP (sβ, 0.72; P = .003) and L-CPP (sβ, 0.75; P = .003) concentrations before dietary phosphate restriction. ΔT-CPP was significantly greater in cats with CKD with uptrend iCa compared to those with downtrend iCa after PRD stabilization (14 105 ± 36 299 AU vs -29 495 ± 49 664 AU; P = .036). CONCLUSIONS AND CLINICAL IMPORTANCE: Calciprotein particle measurement is possible in cats and adds to the assessment of CKD-MBD, particularly the risk of soft tissue mineralization. The trajectory of iCa after PRD might influence CPP concentrations in cats with CKD.
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