Evidence map›Paper›PMID 41806346›Full record

ArticleBulletin of experimental biology and medicine2025

Changes in Repolarizing Currents in Mouse Cardiomyocytes Following Chronic Atorvastatin Exposure.

I Dzhumaniiazova, T S Filatova, G F Zakyrjanova, A V Shamshura, O B Pustovit, D V Abramochkin

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Article in Bulletin of experimental biology and medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

I DzhumaniiazovaLomonosov Moscow State University, Moscow, Russia.
T S FilatovaLomonosov Moscow State University, Moscow, Russia.
G F ZakyrjanovaLomonosov Moscow State University, Moscow, Russia.
A V ShamshuraLomonosov Moscow State University, Moscow, Russia.
O B PustovitLomonosov Moscow State University, Moscow, Russia.
D V AbramochkinLomonosov Moscow State University, Moscow, Russia. abram340@mail.ru.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although statins are among the most frequently prescribed drugs worldwide, their effect on the electrical activity of the heart, especially under chronic exposure, is poorly studied. We analyzed changes in the main repolarizing potassium currents in ventricular cardiomyocytes isolated from mice under chronic atorvastatin exposure. The mice received atorvastatin in drinking water at a dose of 10 mg/kg for 1 month. The whole-cell patch-clamp measurements showed an increase in the ultrarapid delayed rectifier potassium current I

Indexed as

AtorvastatinHydroxymethylglutaryl-CoA Reductase InhibitorsMyocytes, CardiacAction PotentialsAnimalsHeart VentriclesMaleMicePatch-Clamp TechniquesPotassiumAtorvastatinHydroxymethylglutaryl-CoA Reductase InhibitorsPotassiumaction potentialcardiomyocytesion currentspatch-clampstatins

Identifiers

PMID41806346

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.