Evidence map›Paper›PMID 41806342›Full record

ArticleBulletin of experimental biology and medicine2025

Expression of Heat Shock Proteins in Skin Keratinocytes from Adult Patients with Atopic Dermatitis.

I V Elistratova, O V Kandalova, E N Volkova, N P Naydenov, V V Kim, S G Morozov

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Article in Bulletin of experimental biology and medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

I V ElistratovaInstitute of General Pathology and Pathophysiology, Moscow, Russia.
O V KandalovaRussian University of Medicine, Ministry of Health of the Russian Federation, Moscow, Russia.
E N VolkovaInstitute of General Pathology and Pathophysiology, Moscow, Russia.
N P NaydenovInstitute of General Pathology and Pathophysiology, Moscow, Russia.
V V KimInstitute of General Pathology and Pathophysiology, Moscow, Russia.
S G MorozovInstitute of General Pathology and Pathophysiology, Moscow, Russia. biopharm@list.ru.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We compared the expression of heat shock proteins (HSP-27, HSP-60, HSP-70, HSP90) in skin keratinocytes of patients with atopic dermatitis and healthy donors. Keratinocytes were obtained by scraping from apparently intact skin of the forearm. Keratinocytes were stained with monoclonal antibodies and analyzed by flow cytometry. The expression of HSPs in patients was significantly increased in comparison with healthy donors and depended on the disease severity according to the SCORAD index. During remission, HSP expression decreased, but did not reach the control values in most patients. A significant increase in the levels of phosphorylated HSP forms was observed during exacerbation of atopic dermatitis, reflecting the stress activity associated with this condition.

Indexed as

Dermatitis, AtopicHeat-Shock ProteinsKeratinocytesSkinAdultChaperonin 60FemaleHSP27 Heat-Shock ProteinsHSP70 Heat-Shock ProteinsHSP90 Heat-Shock ProteinsHumansMaleMiddle AgedPhosphorylationChaperonin 60Heat-Shock ProteinsHSP27 Heat-Shock ProteinsHSP70 Heat-Shock ProteinsHSP90 Heat-Shock Proteinsatopic dermatitisheat shock proteinskeratinocytesskin

Identifiers

PMID41806342

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.