Evidence map›Paper›PMID 41806269›Full record

Trial reportPsycho-oncology2026

Efficacy of an Online Meaning-Centered Psychotherapy in Caregivers of Advanced Cancer (eMCP-C): A Mixed-Method Pilot Randomized Controlled Trial.

Naomi Takemura, Arthur Cheuk-Man Li, Wing Lok Chan, Sau Fung Yu, Vivian Weiqun Lou, Daniel Yee-Tak Fong, Jessica Kang Qi Lee, Janelle Yorke, Allison J Applebaum

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Psycho-oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Meaning-centered psychotherapy for Chinese caregivers of patients with advanced cancer: Cultural and linguistic adaptation.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Naomi TakemuraSchool of Nursing, The Hong Kong Polytechnic University, Hong Kong SAR, China.ORCID https://orcid.org/0000-0002-2950-5251
Arthur Cheuk-Man LiLKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.ORCID https://orcid.org/0000-0002-6211-9053
Wing Lok ChanDepartment of Clinical Oncology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.ORCID https://orcid.org/0000-0001-9793-9273
Sau Fung YuSchool of Nursing, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.ORCID https://orcid.org/0000-0002-9359-1748
Vivian Weiqun LouDepartment of Social Work and Social Administration, Faculty of Social Sciences, The University of Hong Kong, Hong Kong SAR, China.ORCID https://orcid.org/0000-0001-7000-1306
Daniel Yee-Tak FongSchool of Nursing, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.ORCID https://orcid.org/0000-0001-7365-9146
Jessica Kang Qi LeeSchool of Nursing, The Hong Kong Polytechnic University, Hong Kong SAR, China.
Janelle YorkeSchool of Nursing, The Hong Kong Polytechnic University, Hong Kong SAR, China.ORCID https://orcid.org/0000-0002-1344-5944
Allison J ApplebaumBrookdale Department of Geriatrics and Palliative Medicine, Steven S. Elbaum Family Center for Caregiving, Icahn School of Medicine at Mount Sinai, New York, New York, USA.ORCID https://orcid.org/0000-0002-2140-5635

Funding

NICHE Research Grant 2023/2024
6 · The paper itself

Abstract

backgroundRising advanced cancer incidence globally places profound existential distress and psychological burden on family caregivers. We culturally adapted Meaning-Centered Psychotherapy for Cancer Caregivers (MCP-C) from Western to Chinese context, targeting existential distress through meaning-making processes.

aimsThis pilot randomized controlled trial aimed to examine the feasibility, acceptability, and preliminary effects of an online MCP-C (eMCP-C) among caregivers of patients with advanced cancer.

methodsCaregivers of patients with advanced cancer, experiencing distress related to caregiving, were randomly assigned (1:1) to eMCP-C or enhanced usual care groups. Over 7 weeks, participants received weekly individual session of eMCP-C focusing on meaning making and coping with caregiving, whereas enhanced usual care group received resources for mental health treatment and targeted referrals for specific distress problems. Feasibility outcomes were assessed through questionnaires and semi-structured interviews at 7-week. Efficacy outcomes were assessed by questionnaire at baseline, 7, and 19 weeks.

resultsForty-six caregivers enrolled (26-79 years old), among which thirty-seven (80%) completed the study. Intervention attendance, retention rates, and participant satisfaction were satisfactory. Depression, anxiety, meaning, peace, and self-esteem improved from baseline to immediate and 3-month post-intervention in intervention group. Qualitative analysis revealed three key therapeutic mechanisms: (1) Therapeutic Alliance as a Catalyst for Intrapersonal and Interpersonal Healing, (2) Meaning-making Through Acceptance and Action, and (3) Empowering Through Affirmation and Self-Determined Action.

conclusionsFor Chinese caregivers of patients with advanced cancer, eMCP-C is feasible, well-accepted, and showed preliminary benefits in psychological distress, meaning, peace, and self-esteem, compared to an enhanced usual care group.

Indexed as

CaregiversNeoplasmsPsychotherapyStress, PsychologicalAdaptation, PsychologicalAdultAgedAnxietyDepressionFeasibility StudiesFemaleHumansMaleMiddle AgedPilot ProjectsPsychological Distressadvanced cancercaregiversChinesemeaning‐centeredpsychotherapy

Identifiers

PMID41806269
PMCPMC12974551

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.