Evidence map›Paper›PMID 41806228›Full record

SynthesisObesity surgery2026

Effect of Calcium Citrate Versus Calcium Carbonate on Parathyroid Hormone Levels in Patients Undergoing Bariatric Surgery: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Jamal Rahmani, Nima Baziar, Nasser Malekpour Alamdari, Carlos Eduardo C Martins, Maryam Abbasi, Heitor O Santos

Abstract readSystematic ReviewMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Obesity surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jamal RahmaniCancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Islamic Republic of Iran.
Nima BaziarClinical Research Development Center, Shahid Modarres Educational hospital, Shahid Beheshti University of Medical Sciences, Tehran, Islamic Republic of Iran.
Nasser Malekpour AlamdariCritical Care Quality Improvement Research Center, Shahid Modarres Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Islamic Republic of Iran. Nassermalekpour@Gmail.com.
Carlos Eduardo C MartinsSchool of Medicine, University of São Paulo, São Paulo, Brazil.
Maryam AbbasiDepartment of General Surgery, Shahid Modarres Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Islamic Republic of Iran. maryamabbasi1986@gmail.com.
Heitor O SantosPostgraduate Program, UNIGUAÇU College, Cascavel, Paraná, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Parathyroid hormone (PTH) is important in bariatric patients for understandingcalcium homeostasis and bone health. The effects of calcium carbonate and calcium citrate onPTH levels need further investigation in this population. This systematic review and meta-analysis of randomized clinical trials investigated the effect of calcium citrate versus calciumcarbonate on PTH levels in patients undergoing bariatric surgery, using the PRISMA guidelines. Atotal of 227 participants from four studies were included in the meta-analysis. Pooled analysisshowed no significant differences between the effect of calcium citrate versus calcium carbonateon serum calcium levels (WMD: 0.03 mg/dl, 95% CI: -0.04,0.11;I=35.7%) and PTH levels(WMD: 0 pg/ml, 95%CI: -2.81,2.82;I=73.5). Subgroup analysis showed that a single dose of calcium citrate significantly reduced PTH levels better than calcium carbonate (WMD: -1.17, 95%CI: -2.04,-0.29; I2=0%), but no significant difference was observed in chronic interventions (WMD: 2.05, 95% CI: -3.68, 7.78; I =81.4%). Furthermore, single dose of calcium citrate increased serum levels of calcium AUC (WMD: 1.28, 95% CI: 0.58, 1.99; I =0%) and calcium Cmax (WMD: 0.28, 95% CI: 0.19, 0.37; I =0%), and decreased PTH AUC (WMD: -30.65, 95% CI:-45.49, -15.81; I =0%), more than calcium carbonate. In conclusion, a single dose of calcium citrate is superior to calcium carbonate in reducing PTH levels in patients undergoing bariatric surgery, but no difference was observed over time between the formulations.

Indexed as

Bariatric SurgeryCalcium CarbonateCalcium CitrateObesity, MorbidParathyroid HormoneHumansRandomized Controlled Trials as TopicCalcium CarbonateCalcium CitrateParathyroid HormoneBariatric surgeryCalcium carbonateCalcium citratePTHSerum calcium

Identifiers

PMID41806228

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.