Evidence map›Paper›PMID 41806216›Full record

ArticlePediatric nephrology (Berlin, Germany)2026

Association between grade of congenital hydronephrosis and time to natural resolution.

Virginie Bleau, Anne Tsampalieros, Nick Barrowman, Jon Seymour, Ivan Terekhov, Janusz Feber, Robert L Myette

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Article in Pediatric nephrology (Berlin, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Virginie BleauDivision of Pediatric Nephrology, Children's Hospital of Eastern Ontario, University of Ottawa, Ottawa, ON, Canada.
Anne TsampalierosClinical Research Unit, Children's Hospital of Eastern Ontario, Ottawa, ON, Canada.
Nick BarrowmanClinical Research Unit, Children's Hospital of Eastern Ontario, Ottawa, ON, Canada.
Jon SeymourChildren's Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada.
Ivan TerekhovChildren's Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada.
Janusz FeberDivision of Pediatric Nephrology, Children's Hospital of Eastern Ontario, University of Ottawa, Ottawa, ON, Canada.
Robert L MyetteDivision of Pediatric Nephrology, Children's Hospital of Eastern Ontario, University of Ottawa, Ottawa, ON, Canada. RMyette@cheo.on.ca.ORCID http://orcid.org/0000-0002-6441-8612

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundStandard of care for pregnancy includes a second trimester ultrasound which may lead to incidental findings of fetal uropathies. The most common fetal uropathy is congenital hydronephrosis (CH). There is limited information regarding the natural history of CH. The objective of this study was to describe factors associated with time to natural resolution of CH.

methodsThis is a retrospective cohort study of infants with CH using data from a single hospital's electronic medical record. Between January 2017 and December 2022, infants with CH were identified using ICD-10 codes and were included in the cohort if they had a second ultrasound prior to 2022. Severity of CH was classified using Society for Fetal Urology (SFU) grades. Cox proportional hazards analysis was used to model time to resolution adjusting for age, sex, and initial SFU grade.

resultsOf 209 infants with CH, 126 were included in the cohort, with males predominating (78%). A total of 168 kidney units were included with 84 infants (67%) having only 1 kidney unit affected. In multivariable Cox proportional hazards regression modeling, after adjusting for sex and age at initial ultrasound, initial SFU grade was associated with time to natural resolution (compared to that of grade 1, adjusted hazard ratios for grades 2, 3, and 4 were as follows: 0.59 [95% CI 0.34, 1.01], 0.23 [95% CI 0.12, 0.47], and 0.04 [95% CI 0.01, 0.14]; p < 0.001).

conclusionsOn average, kidney units with not only SFU 4, but also SFU 3, resolved more slowly than those with low-grade hydronephrosis. These findings will assist in counseling parents of children with CH.

Indexed as

HydronephrosisFemaleHumansInfantInfant, NewbornKidneyMalePregnancyProportional Hazards ModelsRemission, SpontaneousRetrospective StudiesSeverity of Illness IndexTime FactorsUltrasonography, PrenatalHydronephrosisPediatricsSFU gradeTime to resolutionUltrasonography

Identifiers

PMID41806216

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.