ArticleBrain imaging and behavior2026
Acute basal ganglia ischemic stroke: a study on structure-function coupling.
Article in Brain imaging and behavior, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
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7 authors.
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Abstract
To investigate the structure-function coupling characteristics in patients with acute ischemic stroke affecting the left and right basal ganglia. Using functional magnetic resonance imaging, include functional magnetic resonance(fMRI) and diffusion tensor imaging (DTI), we analyzed both whole-brain coupling and node coupling in acute ischemic stroke patients (left basal ganglia, L group; right basal ganglia, R group) and healthy controls (healthy controls, HC group). We compared coupling parameters across different groups (Total sample:89; R group sample:34, L group sample:25, HC group sample:30) and analyzed their correlation with clinical scores, such as the Fugl-Meyer Assessment. Whole-brain structural connectivity exhibited a significant positive correlation with functional connectivity across the three groups of subjects. The coupling values of structure-function coupling for the L group ranged from 0.0040 to 0.1576 (0.0631 ± 0.0389), for the R group ranged from 0.0013 to 0.2236 (0.0773 ± 0.0537), and for the HC group ranged from 0.010 to 0.2000 (0.0657 ± 0.0470). Compared to the healthy controls group, the L group exhibited significantly decreased structure-function node coupling in the following regions: dorsolateral prefrontal cortex, inferior frontal gyrus, posterior cingulate gyrus, amygdala, cuneus, inferior occipital gyrus, caudate nucleus, globus pallidus, superior temporal gyrus, and temporal lobes and several nodes. But left putamen significantly increased. Compared to the healthy control group, the R group demonstrated significantly decreased structure-function coupling in the following nodes: insula, anterior cingulate and paracingulate cortex, angular gyrus, and precuneus. After applying FDR (false discovery rate, FDR) correction, only the Area 83 in group L exhibits a statistically significant difference at the node-level coupling on FA and on FN (p < 0.05).At the whole-brain level, only the right hemisphere SC-FC coupling (structural-functional coupling, SC-FC coupling) showed a weak correlation with the Fugl-Meyer Assessment scores (r = 0.366, p = 0.047). The structure-function coupling characteristics in acute ischemic stroke patients affecting the basal ganglia indicate a dynamic reorganization process under pathological conditions. Node coupling serves as an important metric for assessing brain network alterations, providing valuable insights into motor function and rehabilitation outcomes in clinical settings.
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