Trial reportBrain imaging and behavior2026
Acupuncture was associated with improved functional connectivity of the left hippocampal perceptual subregion in amnestic mild cognitive impairment.
Trial report in Brain imaging and behavior, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
10 authors.
Funding
Abstract
Although acupuncture is commonly used to improve cognition and memory in patients with amnesic mild cognitive impairment (aMCI) with impressive effectiveness, its neural mechanism is unknown. This study aims to explore the functional changing patterns of hippocampal subregions in aMCI and identify the neuro-mechanism underlying the clinical efficacy of acupuncture for aMCI. We conducted a randomized, controlled, anonymized study. Patients with aMCI were randomized and allocated to verum acupuncture (VA, n = 24) or sham acupuncture (SA, n = 26) in a 1:1 ratio, with 24 sessions over 8 weeks of treatment. Healthy controls (HCs, n = 34) were also included with no treatment. Resting-state functional connectivity (RSFC) of hippocampal subregions and cognitive impairment scores were investigated before and after acupuncture. Relationships between hippocampal subregion alterations and cognitive measurements were examined. Patients with aMCI exhibited decreased RSFC in the perceptual subregion of the left hippocampus (HIPp.L) with the right middle frontal gyrus (MFG.R) and decreased RSFC in the emotional subregion of the hippocampus with the right triangle section of the inferior frontal gyrus when compared to HCs. The RSFC between HIPp.L and MFG.R was significantly increased after VA but not SA. Furthermore, this RSFC between HIPp.L and MFG.R was negatively correlated with Auditory Verbal Learning Test_ immediate recall in the aMCI before VA and positively correlated with MMSE in the aMCI after VA. We demonstrated that acupuncture could modulate functional dysfunction of the HIPp.L in the aMCI, and RSFC between HIPp.L and MFG.R may underlie the neuro-mechanisms of VA in releasing cognitive impairment of aMCI.
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Registered trials
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