Evidence map›Paper›PMID 41806151›Full record

ArticleGenes & genomics2026

c-Myc regulated long noncoding RNA TRD-AS1 to affect the progression of oral squamous cell carcinoma.

Ziyue Feng, Yuxuan Han, Xiaofeng Qin, Miaoting Fu, Xiangyang Li, Youming Zhu

Abstract read
PubMed Publisher
In one paragraph

Article in Genes & genomics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ziyue FengCollege & Hospital of Stomatology,, Anhui Medical University, Anhui Provincial Key Laboratory of Oral Diseases Research,, Hefei, 230032, China.
Yuxuan HanCollege & Hospital of Stomatology,, Anhui Medical University, Anhui Provincial Key Laboratory of Oral Diseases Research,, Hefei, 230032, China.
Xiaofeng QinCollege & Hospital of Stomatology,, Anhui Medical University, Anhui Provincial Key Laboratory of Oral Diseases Research,, Hefei, 230032, China.
Miaoting FuCollege & Hospital of Stomatology,, Anhui Medical University, Anhui Provincial Key Laboratory of Oral Diseases Research,, Hefei, 230032, China.
Xiangyang LiCollege & Hospital of Stomatology,, Anhui Medical University, Anhui Provincial Key Laboratory of Oral Diseases Research,, Hefei, 230032, China. hlxiangyang@163.com.
Youming ZhuCollege & Hospital of Stomatology,, Anhui Medical University, Anhui Provincial Key Laboratory of Oral Diseases Research,, Hefei, 230032, China. zym1985@ahmu.edu.cn.ORCID 0000-0003-4043-8560

Funding

Excellent Young Scientists Fund of the Natural Science Foundation of Anhui Province 2308085Y23National Natural Science Foundation of China 31970677the Research Level Improvement Plan of Anhui Medical University 2019xkjT010
6 · The paper itself

Abstract

backgroundOral squamous cell carcinoma (OSCC) progression is closely associated with dysregulated oncogenic transcription programs and noncoding RNA networks. c-Myc is a key transcription factor in tumor biology, but the role of c-Myc-regulated long noncoding RNAs such as TRD-AS1 (LNC TRD-AS1) in OSCC progression remains to be clarified.

objectiveTo investigate the effect of c-Myc-regulated LNC TRD-AS1 on the progression of OSCC.

methodsThe effects of c-Myc on LNC TRD-AS1 were detected. Expression of c-Myc and LNC TRD-AS1 in OSCC and paracancerous tissues. Dual luciferase reporter assay verified the binding of c-Myc to the promoter region of LNC TRD-AS1. The localization of LNC TRD-AS1 in OSCC was determined by nucleocytoplasmic isolation assay and RNA FISH experiments. The effects of overexpression, knockdown of LNC TRD-AS1 and rescue experiments on migration, metabolism, and proliferation of OSCC cells were observed by quantitative real-time polymerase chain reaction (qRT-PCR), western blots, scratch tests, Transwell assays, medium color and pH changes, ATP measurement, CCK-8 assays, and colony formation assays.

resultsIt was found that c-Myc positively regulated the expression of LNC TRD-AS1 in OSCC cell lines and tissues. The binding of c-Myc to the LNC TRD-AS1 promoter region was verified by dual-luciferase reporter assays. Both nucleoplasmic separation assays and RNA FISH showed that LNC TRD-AS1 was localized to the nuclei in OSCC cells. Overexpression of LNC TRD-AS1 promoted migration, metabolism and proliferation in OSCC cell lines, while knockdown had the opposite effect.

conclusionc-Myc positively regulated LNC TRD-AS1 in OSCC. LNC TRD-AS1 affected the migration, proliferation and metabolism of OSCC by affecting the tumor acid metabolism.

Indexed as

Carcinoma, Squamous CellMouth NeoplasmsProto-Oncogene Proteins c-mycRNA, Long NoncodingCell Line, TumorCell MovementCell ProliferationDisease ProgressionGene Expression Regulation, NeoplasticHumansMYC protein, humanProto-Oncogene Proteins c-mycRNA, Long Noncodingc-MycENST00000556777LNC TRD-AS1Long noncoding RNAOral squamous cell carcinoma

Identifiers

PMID41806151

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.