SynthesisAnnals of biomedical engineering2026
Organ-on-a-Chip Devices to Simulate the Dentin-Pulp Complex: A Qualitative Systematic Review.
Synthesis in Annals of biomedical engineering, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
purposeTo analyze the development and application of microfluidic devices representative of the dentin-pulp complex.
methodsA systematic literature search was conducted on electronic databases. The inclusion criteria were in vitro studies aimed at developing and/or using microfluidic devices that mimic the dentin-pulp interface. The aspects analyzed included device design, fabrication methods, interface and channel characteristics, culture methods, main outcomes and measurement techniques. The risk of bias was assessed via the QUIN tool.
resultsFive studies were included. Significant variability was observed in device design, construction, channels, and interface characteristics. Only one study incorporated dynamic fluid flow, whereas the others relied on static culture conditions. The main outcomes measured included cell viability, odontoblastic morphology and metabolic activity.
conclusionThis systematic review identified limited research on microfluidic devices that replicate the dentin-pulp complex with high variability in terms of fabrication, design, and materials. Most studies have used static cultures despite the benefits of dynamic flow. Additionally, studies lack detailed information on critical device characteristics. Future research should integrate dynamic features, and comprehensive reporting to improve reproducibility and develop physiologically relevant models.
Indexed as
Identifiers
41806121What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.