Evidence map›Paper›PMID 41806114›Full record

ArticleAnnals of surgical oncology2026

Oncology and Fertility Outcomes for Patients with Stage IC Adult Granulosa Cell Tumor of the Ovary.

Dan Wang, Jiayuan Zhao, Yuan Li, Congwei Jia, Dongyan Cao, Jiaxin Yang, Peng Peng, Junjun Yang, Yang Xiang

Abstract read
PubMed Publisher
In one paragraph

Article in Annals of surgical oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Dan Wang *National Clinical Research Center for Women's Health and Obstetric and Gynecologic Diseases, Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.
Jiayuan Zhao *National Clinical Research Center for Women's Health and Obstetric and Gynecologic Diseases, Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.
Yuan LiNational Clinical Research Center for Women's Health and Obstetric and Gynecologic Diseases, Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.
Congwei JiaDepartment of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Dongyan CaoNational Clinical Research Center for Women's Health and Obstetric and Gynecologic Diseases, Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.
Jiaxin YangNational Clinical Research Center for Women's Health and Obstetric and Gynecologic Diseases, Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.
Peng PengNational Clinical Research Center for Women's Health and Obstetric and Gynecologic Diseases, Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.
Junjun YangNational Clinical Research Center for Women's Health and Obstetric and Gynecologic Diseases, Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China. yangjunjun@pumch.cn.
Yang XiangNational Clinical Research Center for Women's Health and Obstetric and Gynecologic Diseases, Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China. xiangy@pumch.cn.ORCID http://orcid.org/0000-0002-9112-1021

Funding

National Key Clinical Specialty Construction Project U114000National Key Research and Development Program of China 2025YFC2708300
6 · The paper itself

Abstract

backgroundThis study aimed to evaluate the efficacy and safety of fertility-sparing surgery (FSS) for patients with stage IC adult granulosa cell tumors (AGCTs) of the ovary.

methodsA retrospective study was conducted at Peking Union Medical College Hospital, covering data from 1 February 1986 to 28 April 2024, focusing on women with a diagnosis of stage IC AGCTs. The patients were divided into two groups: those who underwent FSS and those who received radical surgery (RS). The primary endpoints were survival and fertility outcomes.

resultsThe study included 84 patients who had stage IC AGCTs (55 patients in the FSS group and 29 patients in the RS group). The median follow-up period was 130 months (range, 9-425 months) in the FSS group and 126 months (range, 9-381 months) in the RS group. The recurrence rates were 61.8% in the FSS group and 37.9% in the RS group. Multivariate analysis identified that the application of FSS was significantly associated with decreased disease-free survival (DFS), whereas older age was an independent risk factor for inferior overall survival (OS). In the FSS group, cystectomy was significantly associated with an increased risk of recurrence related to DFS. Additionally, among the patients in the FSS group, 12 conceived, and 11 successfully delivered a total of 13 children.

conclusionsFertility-sparing surgery should be pursued cautiously, with careful patient selection and comprehensive counseling, in view of the substantial risk for recurrence and the limitations of the current evidence.

Indexed as

Fertility PreservationGranulosa Cell TumorNeoplasm Recurrence, LocalOrgan Sparing TreatmentsOvarian NeoplasmsAdultFemaleFollow-Up StudiesHumansMiddle AgedNeoplasm StagingPregnancyPrognosisRetrospective StudiesSurvival RateYoung AdultAdult granulosa cell tumorFertility-sparing surgeryOncologic outcomeReproductive outcomeStage IC

Identifiers

PMID41806114

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.