ArticleMycopathologia2026
Catheter-Associated Candiduria: Aggregates, Microscopy, and CFU Variability.
Article in Mycopathologia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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4 authors.
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Abstract
Diagnosis of catheter-associated candiduria is limited by absent colony-forming unit (CFU) thresholds and heterogeneous laboratory workflows, complicating patient management. Within a quality-improvement (QI) initiative we aimed to (1) implement and evaluate a standardised quantitative culture (QM) workflow for catheter urine, (2) compare QM with routine semi-quantitative culture (SQM) for CFU detection and reproducibility, and (3) assess whether visible urine aggregates predict Candida spp. presence. From February 2024 to February 2025, we analysed 222 yeast-positive urine samples from 74 catheterised patients. This pilot combined process standardisation, parallel SQM and QM testing, targeted microscopy of aggregate-containing samples, and species identification by CHROMID® Candida agar and MALDI-TOF. Agreement between methods, intra-patient CFU variability over three daily samples, and the predictive value of aggregates were assessed. Aggregates were present in 29/222 samples (13.1%), of which 13 (44.8%) contained Candida spp., mainly C. albicans. No reliable macroscopic features distinguished Candida-positive from -negative aggregates. QM and SQM showed poor agreement (Bowker p < 0.001, κ = 0.17). QM detected growth in samples reported as "sterile" by SQM and provided continuous CFU counts. Cohort-level median QM counts were stable, but 13 patients (17.6%) showed notable variability, with 5 (6.8%) fluctuating > 10
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