Observational studyClinical oral investigations2026
MRI characteristics of diffuse sclerosing osteomyelitis of the mandible and the association of perineural edema with pain relapse: a retrospective cohort study.
Observational study in Clinical oral investigations, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesDiffuse sclerosing osteomyelitis (DSO) is a diagnosis of exclusion with incompletely understood mechanisms underlying acute pain episodes. This study aimed to characterize Magnetic Resonance Imaging (MRI) features of DSO to investigate imaging findings associated with acute pain during disease relapse. MATERIALS AND
methodsThis single-center, retrospective observational study included 14 patients diagnosed with DSO. All subjects underwent MRI using a 3T Siemens MAGNETOM Vida scanner equipped with a 15-channel mandibular coil. MRI datasets were evaluated for cortical bone alterations, lymph node enlargement, contrast enhancement patterns, and soft-tissue or perineural edema.
resultsMRI demonstrated thickened cortical bone (85.7%, 95% CI 57.2–97.8), cortical destruction (35.7%, 95% CI 12.8–64.9%), pathologically enlarged lymph nodes (64.3%, 95% CI 35.1–87.2) and contrast enhancement within the mandibular bone (78.6%, 95% CI 49.2–95.3) and masticatory muscles 42.9%, (95% CI 17.7–71.1) as characteristic features of DSO. Perineural edema was present in 57.1% (95% CI: 28.9–82.3) of all patients and in 100% of patients with active pain relapse.
conclusionIn DSO patients, mandibular-coil MRI can reveal perineural inflammation, particularly perineural edema, which appears to be associated with pain symptoms and may serve as a diagnostic aid in the often-challenging identification of DSO. These observations are based on the present data and do not establish a causal relationship between perineural edema and pain. CLINICAL RELEVANCE: MRI may enhance diagnostic accuracy in DSO, help identify relapse-associated inflammatory changes, and improve understanding of pain mechanisms, thereby supporting more tailored therapeutic strategies.
Indexed as
Identifiers
41806010What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.