Evidence map›Paper›PMID 41805993›Full record

ArticleJournal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie2026

Association between 6-n-propylthiouracil taste phenotypes and the development of initial caries lesions during fixed orthodontic treatment : A prospective cohort study.

Ulaganathan Sangeetha, Balasubramanian Madhan, Shivangi Ramteke, Bhaskar Nivethitha, Madhanraj Selvaraj

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In one paragraph

Article in Journal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ulaganathan SangeethaDivision of Orthodontics and Dentofacial Orthopedics, Department of Dentistry, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.
Balasubramanian MadhanDivision of Orthodontics and Dentofacial Orthopedics, Department of Dentistry, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India. madhanb@hotmail.com.
Shivangi RamtekeDivision of Orthodontics and Dentofacial Orthopedics, Department of Dentistry, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.
Bhaskar NivethithaDivision of Orthodontics and Dentofacial Orthopedics, Department of Dentistry, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.
Madhanraj SelvarajDivision of Orthodontics and Dentofacial Orthopedics, Department of Dentistry, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeWe explored the association between the 6‑n-propylthiouracil (PROP) taste phenotypes and the incidence and severity of initial caries lesions (ICL) during fixed orthodontic treatment.

methodsThe participants were a prospective cohort of 44 fixed orthodontic patients (16 males, 28 females, 18.7 ± 5.5 years) classified as non-tasters (n = 19) and tasters (n = 25) based on their bitter taste perception of PROP. The primary outcome was the cumulative incidence (C

resultsNon-tasters had a higher relative risk (RR) of a tooth developing ICL than tasters at 9 months (C

conclusionThe results suggest a possible role of the individual's taste phenotype in the development and severity of ICL during fixed orthodontic treatment.

Indexed as

Dental cariesEnamel decalcificationFixed orthodontic appliancesTooth demineralizationWhite spot lesion

Identifiers

PMID41805993

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.