Evidence map›Paper›PMID 41805927›Full record

SynthesisNeurosurgical review2026

Stereotactic radiosurgery (SRS) for primary intradural spinal tumors: A systematic review and meta-analysis.

Emil O R Nordin, Vivek Sanker, Philip Heesen, Srinath Hariharan, Olga Ciobanu-Caraus, Maria Jose Cavagnaro, Ikchan Jeon, David Park, Steven Chang, John K Ratliff and 1 more

Abstract readSystematic ReviewMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Neurosurgical review, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Emil O R NordinDepartment of Neurosurgery, Stanford University, Stanford, CA, USA. enordin@stanford.edu.
Vivek SankerDepartment of Neurosurgery, Stanford University, Stanford, CA, USA.
Philip HeesenUniversity of Zurich, Zurich, Switzerland.
Srinath HariharanDepartment of Neurosurgery, Stanford University, Stanford, CA, USA.
Olga Ciobanu-CarausDepartment of Neurosurgery, LMU University Hospital, LMU Munich, Munich, Germany.
Maria Jose CavagnaroDepartment of Neurosurgery, Stanford University, Stanford, CA, USA.
Ikchan JeonDepartment of Neurosurgery, Yeungnam University Hospital, Yeungnam University College of Medicine, Daegu, South Korea.
David ParkDepartment of Neurosurgery, Stanford University, Stanford, CA, USA.
Steven ChangDepartment of Neurosurgery, Stanford University, Stanford, CA, USA.
John K RatliffDepartment of Neurosurgery, Stanford University, Stanford, CA, USA.
Atman DesaiDepartment of Neurosurgery, Stanford University, Stanford, CA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

While primary intradural spinal tumors (PIST) are commonly treated by surgery, the use of stereotactic radiosurgery (SRS) is typically considered when patients are either poor surgical candidates or have recurrent or unresectable tumors. However, the optimal use of SRS in the treatment of PISTs and its efficacy remains relatively unclear. Our aim with this study was to investigate the therapeutic response among PISTs treated with SRS. We performed a systematic literature search in five databases: Medline, Embase (Ovid), Scopus, Web of Science Advance and Cochrane Central from inception to July 8th 2024. We included studies that reported on outcomes among PISTs treated with SRS and meta-analyzed the proportions of recurrence and local control (LC) among them. The quality of included studies was assessed using the MINORS tool for non-randomized studies. We identified 14 studies and classified them by follow-up duration. 4 studies had mean or median follow-up times of less than 3 years (short-term follow-up) and 10 studies had greater than 3 years follow-up (long-term follow-up). The mean and median follow up times ranged from 33 to 54.3 months, and 18 to 60 months, respectively. The overall pooled proportion of short-term LC was 0.98 [95% CI: 0.90-1.00], while long-term LC was 0.94 [95% CI: 0.89; 0.97]. The overall pooled proportion of recurrence was 0.01 [95% CI: 0.00; 0.05] for short-term follow-up and 0.05 [95% CI: 0.03; 0.09] for long-term. Subgroup analyses included long-term LC for hemangioblastomas, meningiomas, schwannomas, and neurofibromas, as well as short-term recurrence for meningiomas and schwannomas. Among subgroups, meningiomas showed the best long-term LC and short-term recurrence, with pooled proportions of 0.99 [95% CI: 0.37; 1.00] and 0.02 [95% CI: 0.00; 0.14], respectively. Our results suggest that treating PISTs with SRS achieves favorable outcomes in terms of LC and recurrence. Meningiomas appear to have the best treatment response in terms of LC, which may be a result of their tumor characteristics. However, our findings should be interpreted with caution, as heterogeneity in how studies defined LC may introduce bias into the pooled estimates.

Indexed as

RadiosurgerySpinal Cord NeoplasmsHumansNeoplasm Recurrence, LocalTreatment OutcomeIntradural tumorsMeningiomaSchwannomaStereotactic radiosurgery

Identifiers

PMID41805927

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.