Evidence map›Paper›PMID 41805728›Full record

ArticleChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2026

The Endoscopic ExtraForaminal TransChoroid (EFTC) Approach in the Management of Pineal Tumors: Gross Total Resection through a Single Burr Hole.

Francesca Vitulli, Marco Lorenzetti, Anca-Mihaela Vasilica, Zita Reisz, Ana Dias, Jane Leitch, Ata Siddiqui, Jean-Marie U-King Im, Erika Pace, Henry Mandeville and 3 more

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Article in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

13 authors.

Francesca VitulliDepartment of Neurosurgery, King's College Hospital NHS Foundation Trust, Denmark Hill, London, England, UK. vitullifrancesca@gmail.com.
Marco LorenzettiDepartment of Neurosurgery, King's College Hospital NHS Foundation Trust, Denmark Hill, London, England, UK.
Anca-Mihaela VasilicaSchool of Medicine, University College London, London, England, UK.
Zita ReiszClinical Neuropathology, King's College Hospital NHS Foundation Trust, Denmark Hill, London, England, UK.
Ana DiasDepartment of Neurosurgery, King's College Hospital NHS Foundation Trust, Denmark Hill, London, England, UK.
Jane LeitchEpsom and St Helier University Hospitals NHS Trust, Epsom, England, UK.
Ata SiddiquiDepartment of Neurosurgery, King's College Hospital NHS Foundation Trust, Denmark Hill, London, England, UK.
Jean-Marie U-King ImDepartment of Neurosurgery, King's College Hospital NHS Foundation Trust, Denmark Hill, London, England, UK.
Erika PaceDepartment of Radiology, The Royal Marsden NHS Foundation Trust, London, England, UK.
Henry MandevilleDivision of Radiotherapy and Imaging, The Institute of Cancer Research, London, England, UK.
Paola AngeliniAdolescent Oncology Drug Development Unit, The Royal Marsden NHS Foundation Trust, London, England, UK.
Fernando CarcellerAdolescent Oncology Drug Development Unit, The Royal Marsden NHS Foundation Trust, London, England, UK.
Bassel ZebianDepartment of Neurosurgery, King's College Hospital NHS Foundation Trust, Denmark Hill, London, England, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pineal region tumors pose a significant surgical challenge due to their deep location and proximity to critical neurovascular structures. Endoscopic techniques, particularly the transchoroid approach, have expanded the possibilities for minimally invasive access to the posterior third ventricle. In select cases, this route may not only allow simultaneous biopsy and third ventriculostomy but also meaningful tumour resection while limiting morbidity. We report the case of an 11-year-old male presenting with headache, drowsiness, vomiting and diplopia. Imaging demonstrated a heterogeneous pineal mass with features suggestive of teratoma. Serum markers revealed markedly elevated β-HCG with normal AFP. The radiological picture coupled with the tumour markers was consistent with a mixed malignant germ cell tumour. An endoscopic third ventriculostomy (ETV) and endoscopic extraforaminal transchoroid (EFTC) approach were planned through a single burr hole with the aim of cerebrospinal fluid (CSF) diversion, providing a tissue sample and debulking if possible and appropriate. The identification of mature teratomatous components on smear and a favorable dissection plane enabled and justified gross total resection through the single burr hole. Histopathology confirmed mature and immature teratomatous tissue with a 5-10% germinomatous component. The postoperative course was uneventful, and the patient completed chemotherapy followed by proton beam radiotherapy, remaining recurrence-free at the latest follow-up of over two years. This case represents the first reported gross total resection (GTR) of a pineal tumour achieved via an endoscopic EFTC approach and highlights its potential as a safe and effective minimally invasive route for lesions in the posterior third ventricle, enabling complete resection in select patients.

Indexed as

Brain NeoplasmsNeuroendoscopyPineal GlandPinealomaTeratomaVentriculostomyChildHumansMaleThird VentricleEndoscopic monoportal surgeryEndoscopic transchoroid approachGerm cell tumorPaediatric neurosurgeryPineal tumor

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.