Evidence map›Paper›PMID 41805571›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

A synthetic ERFVII-dependent circuit in yeast sheds light on the regulation of early hypoxic responses of plants.

Mikel Lavilla-Puerta, Yuming He, Luca Piccinini, Lorenzo Di Paco, Antonis Papachristodoulou, Francesco Licausi, Beatrice Giuntoli

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. A synthetic ERFVII-dependent circuit in yeast sheds light on the regulation of early hypoxic responses of plants.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Mikel Lavilla-PuertaInstitute of Plant Sciences, Scuola Superiore Sant'Anna, Pisa 56127, Italy.ORCID 0000-0001-9920-9020
Yuming HeDepartment of Biology, University of Oxford, Oxford OX1 3RB, United Kingdom.ORCID 0000-0001-8530-5652
Luca PiccininiInstitute of Plant Sciences, Scuola Superiore Sant'Anna, Pisa 56127, Italy.ORCID 0000-0002-5529-4160
Lorenzo Di PacoInstitute of Plant Sciences, Scuola Superiore Sant'Anna, Pisa 56127, Italy.ORCID 0009-0009-6664-9535
Antonis PapachristodoulouDepartment of Engineering Science, University of Oxford, Oxford OX1 3PJ, United Kingdom.ORCID 0000-0002-3565-8967
Francesco LicausiDepartment of Biology, University of Oxford, Oxford OX1 3RB, United Kingdom.ORCID 0000-0003-4769-441X
Beatrice GiuntoliDepartment of Biology, University of Pisa, Pisa 56127, Italy.ORCID 0000-0003-4968-4071

Funding

EC | European Research Council (ERC) 101001320UKRI | Biotechnology and Biological Sciences Research Council (BBSRC) BB/T008784/1UKRI | Biotechnology and Biological Sciences Research Council (BBSRC) CBR00770UKRI | Engineering and Physical Sciences Research Council (EPSRC) APP77999UKRI | Engineering and Physical Sciences Research Council (EPSRC) EP/X031470/1UKRI | Engineering and Physical Sciences Research Council (EPSRC) EP/Y014073/1
6 · The paper itself

Abstract

Plants face hypoxic conditions either chronically, as particular tissues are characterized by fluctuating or stable low oxygen levels, or acutely, when flooded. In vascular plants, transcriptional adaptive responses to hypoxia are rapidly mounted by Ethylene Response Factors VII (ERFVIIs), regulated by Plant Cysteine Oxidases (PCOs) through the cysteine branch of the N-degron pathway (Cys-NDP) for oxygen sensing. However, this relatively simple regulatory circuit, consisting of both constitutively expressed as well as hypoxia-inducible ERFVIIs and PCOs, interacts with diverse signaling cues and pathways invoked by hypoxia. To understand the share of the PCO-mediated oxygen sensing mechanism in the production of hypoxia responses, we insulated the PCO/ERFVII circuit from

Indexed as

ArabidopsisArabidopsis ProteinsDNA-Binding ProteinsSaccharomyces cerevisiaeGene Expression Regulation, PlantOxygenSignal TransductionTranscription FactorsArabidopsis ProteinsDNA-Binding ProteinsOxygenRAP2.12 protein, ArabidopsisTranscription FactorsArabidopsis thalianahypoxiaN-degron pathwaySaccharomyces cerevisiaesynthetic biology

Identifiers

PMID41805571
PMCPMC12994171

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.