Evidence map›Paper›PMID 41805401›Full record

ArticleNeurology2026

Association of Interictal Respiratory Variability and Severity of Postictal Hypoxemia After Generalized Convulsive Seizures.

Jack Caplan, Laura Vilella, Paula Lee, Roshni Nair, Deidre Dragon, Linder H Wendt, Patrick Ten Eyck, Jennifer A Ogren, Nuria Lecumberri, Johnson P Hampson and 15 more

Abstract read
In one paragraph

Article in Neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Jack CaplanDepartment of Neurology, University of Iowa, Iowa City.ORCID 0009-0007-8727-3608
Laura VilellaDepartment of Neurology, Hospital del Mar, Barcelona, Spain.ORCID 0000-0003-2621-4413
Paula LeeDepartment of Neurology, University of Iowa, Iowa City.ORCID 0000-0002-2579-1203
Roshni NairDepartment of Neurology, University of Iowa, Iowa City.
Deidre DragonDepartment of Neurology, University of Iowa, Iowa City.ORCID 0009-0008-9451-9992
Linder H WendtInstitute for Clinical and Translational Science, University of Iowa, Iowa City.ORCID 0000-0003-1832-0486
Patrick Ten EyckInstitute for Clinical and Translational Science, University of Iowa, Iowa City.ORCID 0000-0002-5041-0708
Jennifer A OgrenDepartment of Neurobiology and the Brain Research Institute, University of California at Los Angeles.ORCID 0009-0007-3857-8376
Nuria LecumberriDepartment of Neurology, University of Texas Health Science at Houston.ORCID 0000-0002-6067-7414
Johnson P HampsonDepartment of Neurology, University of Texas Health Science at Houston.ORCID 0000-0002-6087-3888
M R Sandhya RaniDepartment of Neurology, University of Texas Health Science at Houston.ORCID 0009-0009-1344-2012
Beate DiehlQueen Square Institute of Neurology, University College London, United Kingdom.ORCID 0000-0002-6896-854X
Daniel FriedmanDepartment of Neurology, NYU Langone Health, New York.ORCID 0000-0003-1068-1797
Orrin DevinskyDepartment of Neurology, NYU Langone Health, New York.ORCID 0000-0003-0044-4632
Lisa M BatemanDepartment of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA.ORCID 0000-0002-4024-1533
Ronald M HarperDepartment of Neurobiology and the Brain Research Institute, University of California at Los Angeles.ORCID 0000-0001-6469-9429
Shiqiang TaoDepartment of Neurology, University of Texas Health Science at Houston.ORCID 0000-0003-1515-3184
Guo-Qiang ZhangDepartment of Neurology, University of Texas Health Science at Houston.ORCID 0000-0002-3663-1109
Maromi NeiDepartment of Neurology, Thomas Jefferson University, Philadelphia, PA.ORCID 0000-0001-7197-3094
Stephan U SchueleDepartment of Neurology, Northwestern Feinberg School of Medicine, Chicago, IL; and.ORCID 0000-0003-3261-7120
Samden LhatooDepartment of Neurology, University of Texas Health Science at Houston.ORCID 0000-0002-0260-3855
George B RichersonDepartment of Neurology, University of Iowa, Iowa City.ORCID 0000-0001-5696-1554
Brian GehlbachDepartment of Internal Medicine, University of Iowa, Iowa City.ORCID 0000-0003-3160-1741
Rup K SainjuDepartment of Neurology, University of Iowa, Iowa City.ORCID 0000-0002-8414-1972
Center for SUDEP Research (CSR)

Funding

The role of central CO2 chemosensitivity in postictal respiratory depression and SUDEPR01NS113764 · NINDS · UNIVERSITY OF IOWA · PI Brian Gehlbach, GEORGE B RICHERSON · 2019 to 2026
$5.5M
NINDS NIH HHS R01 NS113764
6 · The paper itself

Abstract

BACKGROUND AND

objectivesSevere hypoxemia after generalized convulsive seizures (GCSs) can trigger neural injury and is a potential biomarker for sudden unexpected death in epilepsy (SUDEP). Some degree of variability in interbreath interval is normal, but increased variability may suggest dysfunctional breathing control and may be associated with severe postictal hypoxemia. We evaluated the relationship between interictal breathing variability and severity and duration of hypoxemia after GCS.

methodsWe prospectively collected video-EEG, respiratory flow and effort, pulse oximetry (SpO

resultsOf 2,506 participants enrolled, 257 (141 [∼54%] female; mean age = 37.9 years) had ≥1 GCS, but only 152 GCS in 123 had evaluable respiratory data. Multivariable model for hypoxemia duration showed that SpO DISCUSSION: Measures of interictal respiratory variability are associated with severe and prolonged hypoxemia after GCS. Increased interictal respiratory variability suggests baseline respiratory dysregulation in some PWE and may be a surrogate for SUDEP risk.

Indexed as

Epilepsy, GeneralizedHypoxiaRespirationSeizuresAdultElectrocardiographyElectroencephalographyFemaleHumansMaleOximetryProspective StudiesSeverity of Illness Index

Identifiers

PMID41805401
PMCPMC13034677

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.