ArticlemBio2026
Guanylate-binding proteins balance iNOS/Arg-1 in myeloid cells during
Lucy Fry, Het Adhvaryu, Hayden Roys, Anne Bowlin, Gopinath Venugopal, Jordan T Bird, Charity Washam, Masahiro Yamamoto, Jörn Coers, Stephanie Byrum and 2 more
Abstract read
In one paragraphArticle in mBio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
12 authors.
Lucy FryDepartment of Microbiology and Immunology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.ORCID 0000-0001-7270-5315 Het AdhvaryuDepartment of Microbiology and Immunology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.ORCID 0009-0002-4385-1318 Hayden RoysDepartment of Microbiology and Immunology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Anne BowlinDepartment of Microbiology and Immunology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Gopinath VenugopalDepartment of Microbiology and Immunology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Jordan T BirdDepartment of Biochemistry and Molecular Biology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Charity WashamDepartment of Biochemistry and Molecular Biology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Masahiro YamamotoDepartment of Immunoparasitology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan.
Jörn CoersDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, USA.ORCID 0000-0001-8707-4608 Stephanie ByrumDepartment of Biochemistry and Molecular Biology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Daniel VothDepartment of Microbiology and Immunology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.ORCID 0000-0002-7631-7827 Tiffany WeinkopffDepartment of Microbiology and Immunology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.ORCID 0000-0002-5239-2486 Funding
Expanding Translational Research in ArkansasUL1TR003107 · NCATS · UNIV OF ARKANSAS FOR MED SCIS · PI JAMES, LAURA P · 2019 to 2023
$21.6MStudy of the Cell-specific Inflammasome Responses During Defense Against Gram-negative BacteriaP20GM103625 · NIGMS · UNIV OF ARKANSAS FOR MED SCIS · PI SMELTZER, MARK S · 2012 to 2021
$21.5MPilot Grant ProgramP30GM145393 · NIGMS · UNIV OF ARKANSAS FOR MED SCIS · PI MARK S SMELTZER · 2022 to 2026
$7.6MJ. NRSA TrainingTL1TR003109 · NCATS · UNIV OF ARKANSAS FOR MED SCIS · PI SEXTON, KEVIN WAYNE · 2019 to 2023
$1.5MSystems Pharmacology and Toxicology Training ProgramT32GM106999 · NIGMS · UNIV OF ARKANSAS FOR MED SCIS · PI PRATHER, PAUL L · 2013 to 2022
$1.4MNCATS NIH HHS TL1 TR003109NCATS NIH HHS UL1 TR003107NIGMS NIH HHS P20 GM103625NIGMS NIH HHS P30 GM145393NIGMS NIH HHS T32 GM106999
6 · The paper itselfAbstract
Cutaneous leishmaniasis (CL) is a debilitating neglected tropical disease characterized by lesions that can range from self-healing to permanent disfiguration. A predominant Th1 response, which stimulates IFN-γ production, is crucial for parasite control during self-healing CL. While IFN-γ primarily activates macrophages to produce nitric oxide via inducible nitric oxide synthase (iNOS), leading to parasite control, it also activates other downstream pathways involved in cell autonomous immunity. One such pathway is the activation of guanylate-binding proteins (Gbps), a class of interferon-inducible GTPases. However, the role of Gbps during CL has been minimally explored. Utilizing RNA-Seq, we found that
Indexed as
ArginaseGTP-Binding ProteinsLeishmania majorLeishmaniasis, CutaneousMyeloid CellsNitric Oxide Synthase Type IIAnimalsFemaleInterferon-gammaMacrophagesMiceMice, Inbred C57BLMice, KnockoutArg1 protein, mouseArginaseGTP-Binding ProteinsInterferon-gammaNitric Oxide Synthase Type IINos2 protein, mouseguanylate-binding proteinsLeishmanialeishmaniasismacrophages
Identifiers
PMID41805192
PMCPMC13059736
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