ArticleJournal of natural products2026
Comparative Genomics and Metabolomics of Domesticated, Pladienolide-Producing
Barbara I Adaikpoh, Taylor Kornfuehrer, Yitao Dai, Galen Ptacek, Bruno S Paulo, Talia Cheifetz, Brendan Duggan, James J La Clair, Michael D Burkart, Alessandra S Eustáquio
Abstract read
In one paragraphArticle in Journal of natural products, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
10 authors.
Barbara I AdaikpohDepartment of Pharmaceutical Sciences, Retzky College of Pharmacy, University of Illinois Chicago, Chicago, Illinois 60601, United States.ORCID 0000-0003-0894-9563 Taylor KornfuehrerDepartment of Pharmaceutical Sciences, Retzky College of Pharmacy, University of Illinois Chicago, Chicago, Illinois 60601, United States.
Yitao DaiDepartment of Pharmaceutical Sciences, Retzky College of Pharmacy, University of Illinois Chicago, Chicago, Illinois 60601, United States.
Galen PtacekDepartment of Pharmaceutical Sciences, Retzky College of Pharmacy, University of Illinois Chicago, Chicago, Illinois 60601, United States.
Bruno S PauloDepartment of Pharmaceutical Sciences, Retzky College of Pharmacy, University of Illinois Chicago, Chicago, Illinois 60601, United States.ORCID 0000-0002-1521-5034 Talia CheifetzDepartment of Pharmaceutical Sciences, Retzky College of Pharmacy, University of Illinois Chicago, Chicago, Illinois 60601, United States.
Brendan DugganSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California 92093, United States.
James J La ClairDepartment of Chemistry and Biochemistry, University of California San Diego, La Jolla, California 92093, United States.
Michael D BurkartDepartment of Chemistry and Biochemistry, University of California San Diego, La Jolla, California 92093, United States.ORCID 0000-0002-4472-2254 Alessandra S EustáquioDepartment of Pharmaceutical Sciences, Retzky College of Pharmacy, University of Illinois Chicago, Chicago, Illinois 60601, United States.ORCID 0000-0002-7852-7844 Funding
Research Training in Natural Product Complementary and Integrative HealthT32AT007533 · NCCIH · UNIVERSITY OF ILLINOIS AT CHICAGO · PI Joanna E Burdette, JIMMY ORJALA · 2013 to 2026
$4.3MEnabling a rapid transition from synthase to structureR21CA280558 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BURKART, MICHAEL D., EUSTAQUIO, ALESSANDRA S · 2024 to 2024
$422kNCCIH NIH HHS T32 AT007533NCI NIH HHS R21 CA280558
6 · The paper itselfAbstract
Laboratory domestication of bacteria can negatively affect natural product production. This problem continues to plague discovery and development efforts. In this study, we investigated pladienolides from
Indexed as
Epoxy CompoundsGenomicsMacrolidesMetabolomicsStreptomycesMolecular StructureRNA, Ribosomal, 16SEpoxy CompoundsMacrolidespladienolide BRNA, Ribosomal, 16S
Identifiers
PMID41805010
PMCPMC13479560
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