Evidence map›Paper›PMID 41804931›Full record

ArticleEarly intervention in psychiatry2026

Sleep in Early Psychosis and Bipolar Disorder: Preliminary Results on Actigraphic and Self-Reported Markers of Vulnerability.

Valentina Baldini, Francesca Iannucci, Noemi Venezia, Francesco Pasquino, Martina Gnazzo, Diana de Ronchi, Stefano Vandi, Giuseppe Plazzi, Lorenzo Pelizza, Marco Menchetti

Abstract read
In one paragraph

Article in Early intervention in psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Valentina BaldiniDepartment of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.
Francesca IannucciDepartment of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.
Noemi VeneziaDepartment of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.
Francesco PasquinoDepartment of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.
Martina GnazzoDepartment of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy.
Diana de RonchiDepartment of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.
Stefano VandiDepartment of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.
Giuseppe PlazziDepartment of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy.ORCID https://orcid.org/0000-0002-1051-0472
Lorenzo PelizzaDepartment of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.ORCID https://orcid.org/0000-0003-4746-2061
Marco MenchettiDepartment of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSleep disturbances are common in the early stages of psychosis and bipolar disorder and are increasingly regarded as transdiagnostic risk factors for symptom severity and suicidality. However, few studies have simultaneously examined both subjective and objective sleep changes during this early illness phase.

methodsThis cross-sectional study included patients within 12 months of the onset of psychosis or bipolar disorder and matched healthy controls. Patients completed standardised questionnaires including the Pittsburgh Sleep Quality Index (PSQI), Epworth Sleepiness Scale (ESS), Beck Depression Inventory (BDI), Mood Disorder Questionnaire (MDQ) and Prodromal Questionnaire-16 (PQ-16). Actigraphy was recorded for seven consecutive nights in both groups.

resultsTwenty patients (11 with psychosis, 9 with bipolar disorder) and 20 healthy controls were assessed. Most patients reported poor sleep quality (70%), depressive symptoms (60%) and suicidal thoughts (65%). Poor sleep quality was strongly linked to depressive symptoms (r = 0.76) and prodromal features (r = 0.69). Actigraphy showed reduced total sleep time in patients compared to controls (388 vs. 449 min) and longer sleep latency in bipolar patients than in those with psychosis (161 vs. 80 min).

conclusionSleep disturbances are common during the first year of psychosis and bipolar disorder. Subjective sleep issues are closely linked to depression, prodromal psychotic symptoms and suicidal thoughts, while actigraphy shows disorder-specific differences. Routine evaluation of both subjective and objective sleep may serve as early indicators of vulnerability and guide intervention strategies in severe mental illness.

Indexed as

Bipolar DisorderPsychotic DisordersSleep Wake DisordersActigraphyAdultCase-Control StudiesCross-Sectional StudiesDepressionFemaleHumansMaleProdromal SymptomsSelf ReportSleep DurationSuicidal IdeationYoung Adultactigraphybipolar disorderdepressionprodromal symptomspsychosissleep disturbancessuicidal ideation

Identifiers

PMID41804931
PMCPMC12973353

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.