ArticleJournal of the American Heart Association2026
Placental Abruption, Preterm Delivery, and Cardiovascular Disease in Twin Offspring.
Article in Journal of the American Heart Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Cardiovascular Disease in Singleton Offspring Born of Pregnancies Complicated by Placental Abruption: A Population-Based Retrospective Cohort Study.Journal of the American Heart Association · 2026Article
- Association between adverse obstetric history and perinatal outcomes in singleton and twin pregnancies: a retrospective study.Frontiers in medicine · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
backgroundIn utero exposures to certain pathologies during pregnancy increase offspring cardiovascular disease (CVD) risks, and pregnancy complications and CVD risks are higher in twins than in singletons. However, the association between placental abruption and nonfatal incident CVD in twin offspring, and whether the abruption effects are mediated through preterm delivery, is unknown.
methodsWe used the PACER (Placental Abruption and Cardiovascular Event Risk) offspring cohort, which links births to hospitalizations and mortality records in New Jersey from 1993 to 2020 (28 years of follow-up) and is restricted to twin offspring. In a Cox model, we estimated the counterfactual decomposition of the abruption-CVD association into a natural direct and indirect effect through preterm delivery.
resultsOf 116 796 twin births, 2597 (2.2%) were complicated by abruption. The rate of incident CVD was higher among abruption than nonabruption births (1560 versus 577 per 100 000 person-years). Abruption was associated with a 2.47-fold increased risk of CVD in the twin offspring, with similar risks for heart disease and stroke. Results indicated that 40% of the total effect was mediated through preterm delivery <37 weeks; the proportion mediated increased with earlier gestational ages at delivery. These risks persisted after accounting for unmeasured confounding bias.
conclusionsPlacental abruption is associated with higher CVD risk in twins through early adulthood, with substantial mediation of effects through preterm delivery. Efforts to optimize obstetric care for pregnant women carrying twins to reduce the risk of abruption may be worthy of consideration. This may translate to public health benefits in reducing CVD in twin offspring.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.