Evidence map›Paper›PMID 41804824›Full record

Trial reportJournal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine2026

Deresuscitation Informed by Ultrasound in Patients With Septic Shock Trial: A Pilot Randomized Controlled Study.

Brendan Innes, Christopher Allison, Nicholas Seidler, Burton Shen, Andrew Fried, Gary Phillips, Andrew Levinson, Adeel Abbasi

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Brendan InnesDepartment of Emergency Medicine, Division of Emergency Critical Care, Stanford University School of Medicine, Palo Alto, California, USA.
Christopher AllisonDepartment of Medicine, Division of Pulmonary and Critical Care Medicine, University of Massachusetts Bay State, Springfield, Massachusetts, USA.
Nicholas SeidlerWarren Alpert Medical School of Brown University, Providence, Rhode Island, USA.ORCID https://orcid.org/0009-0007-0486-6847
Burton ShenDepartment of Medicine, Division of Pulmonary, Critical Care & Sleep Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA.
Andrew FriedDepartment of Emergency Medicine, Maine Medical Center, Portland, Maine, USA.
Gary PhillipsOhio State University Medical Center, Center for Biostatistics, Columbus, Ohio, USA.
Andrew LevinsonDepartment of Medicine, Division of Pulmonary, Critical Care & Sleep Medicine, Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA.
Adeel AbbasiDepartment of Medicine, Division of Pulmonary, Critical Care & Sleep Medicine, Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA.ORCID https://orcid.org/0000-0001-7887-243X

Funding

Uncoupling of IL-1 beta and VEGF-A Crosstalk Contributes to Impaired Arteriogenesis Response to Ischemia in Chronic Diabetes MellitusP20GM103652 · NIGMS · OCEAN STATE RESEARCH INSTITUTE, INC. · PI HARRINGTON, ELIZABETH O · 2013 to 2022
$21.3M
Francis Family FoundationNIGMS NIH HHS P20 GM 103652NIGMS NIH HHS P20 GM103652
6 · The paper itself

Abstract

objectivesThe venous excess ultrasound (VExUS) can be used at the point-of-care to identify venous overload and end-organ congestion in an effort to individually tailor resuscitation and deresuscitation in patients with septic shock.

methodsWe conducted a pilot randomized controlled feasibility trial of VExUS-guided fluid management in adult patients with septic shock. Participants were randomized to VExUS-guided fluid management or usual care. Daily ultrasounds were performed on all participants; in the VExUS-guided study arm, the clinical care team was informed of the VExUS results and given a fluid management recommendation (the intervention).

resultsWe enrolled 19 participants; 12 (63%) were randomized to the VExUS arm. The intervention period fluid balance was -65 mL (interquartile range [IQR] -1733 to 2016) in the VExUS arm compared to 2608 mL (IQR -435 to 4460) in the usual care arm (p = .21). The secondary outcomes of acute kidney injury, respiratory failure, hospital, and 30-day mortality did not differ significantly between the 2 arms; although the rates were lower in the VExUS arm.

conclusionsWe demonstrate that VExUS-guided fluid management in patients with septic shock is feasible, was not associated with an increased risk of adverse events, and may reduce the volume of fluids administered.

Indexed as

Fluid TherapyShock, SepticUltrasonography, InterventionalAgedFeasibility StudiesFemaleHumansMaleMiddle AgedPilot ProjectsUltrasonographyderesuscitationpilot randomized controlled feasibility trialseptic shockvenous excess ultrasound (VExUS)

Identifiers

PMID41804824
PMCPMC13356412

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.