Evidence map›Paper›PMID 41804802›Full record

ArticleSleep2026

Pediatric SleepNet: a deep learning network for reliable pediatric sleep staging across developmental stages.

Ayush Tripathi, Arnav Gupta, Wolfgang Ganglberger, Samuel Waters, Haoqi Sun, Samaneh Nasiri, Ayan Mitra, Katie L Stone, Emmanuel Mignot, Dennis Hwang and 7 more

Abstract read
In one paragraph

Article in Sleep, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Ayush TripathiDepartment of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, United States.ORCID 0000-0002-7944-2260
Arnav GuptaDepartment of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, United States.ORCID 0009-0003-4818-2130
Wolfgang GanglbergerDepartment of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, United States.ORCID 0000-0002-6029-2450
Samuel WatersDepartment of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, United States.
Haoqi SunDepartment of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, United States.ORCID 0000-0002-5041-8312
Samaneh NasiriDepartment of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, United States.
Ayan MitraDepartment of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, United States.
Katie L StoneDepartment of Epidemiology and Biostatistics, University of California, San Francisco, United States.
Emmanuel MignotStanford University, Palo Alto, CA, United States.ORCID 0000-0002-6928-5310
Dennis HwangKaiser Permanente, San Bernardino County Sleep Disorders Center, San Bernardino, CA, United States.
Matthew A ReynaEmory University School of Medicine, Atlanta, GA, United States.ORCID 0000-0003-4688-7965
Lynn Marie TrottiEmory University School of Medicine, Atlanta, GA, United States.ORCID 0000-0003-2329-6847
Gari D CliffordEmory University School of Medicine, Atlanta, GA, United States.
Kiran MaskiHarvard Medical School, Boston, MA, United States.ORCID 0000-0003-4073-4036
Umakanth KatwaHarvard Medical School, Boston, MA, United States.
Robert J ThomasHarvard Medical School, Boston, MA, United States.ORCID 0000-0002-5575-3953
M Brandon WestoverDepartment of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, United States.ORCID 0000-0003-4803-312X

Funding

Late-onset Unexplained Epilepsy as a Risk Factor for DementiaR01NS130119 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI Alice D Lam · 2023 to 2026
$8.7M
Data-Driven Sleep Biomarkers of Brain Health, Heart Health, and MortalityR01HL161253 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI CLIFFORD, GARI DAVID, MIGNOT, EMMANUEL J · 2022 to 2025
$8.3M
Comparative Safety of Seizure Prophylaxis within the Medicare ProgramR01AG073410 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI Lidia Maria Veras Rocha de Moura · 2021 to 2026
$4.1M
Low Neurophysiologic Resistance to Anesthetics as a Marker of Preclinical/Prodromal Alzheimer's Disease and Neurovascular Pathology, Delirium risk and InattentionR01AG073598 · NIA · STANFORD UNIVERSITY · PI Miles Berger · 2022 to 2026
$3.8M
Investigation of Sleep in the Intensive Care Unit (ICU-SLEEP)R01NS102190 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI WESTOVER, MICHAEL BRANDON · 2018 to 2022
$3.2M
Prospective Validation of Neurophysiologic Outcome Prediction in Acute Brain InjuryR01NS126282 · NINDS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI Aaron F Struck, Michael Brandon Westover · 2023 to 2026
$2.9M
Big Data and Deep Learning for the Interictal-Ictal-Injury ContiuumR01NS107291 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI WESTOVER, MICHAEL BRANDON · 2018 to 2022
$2.8M
Establishing a Brain Health Index from the Sleep ElectroencephalogramRF1NS120947 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI CASH, SYDNEY S, THOMAS, ROBERT JOSEPH · 2021 to 2021
$2.4M
Comparative Effectiveness of EEG-Guided Anti-Seizure Treatment in Acute Brain InjuryR01NS131347 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI Sahar F Zafar · 2024 to 2026
$1.9M
Establishing a Brain Health IndexR01NS120947 · NINDS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI CASH, SYDNEY S, THOMAS, ROBERT JOSEPH · 2024 to 2025
$1.6M
NHLBI NIH HHS R01 HL161253NHLBI NIH HHS R01HL161253NIA NIH HHS R01AG073410NIA NIH HHS R01AG073598NIH R01NS126282NIH R01NS131347NINDS NIH HHS R01 NS102190NINDS NIH HHS R01 NS107291NINDS NIH HHS R01 NS120947NINDS NIH HHS R01 NS126282NINDS NIH HHS R01 NS130119NINDS NIH HHS R01NS130119NINDS NIH HHS RF1 NS120947
6 · The paper itself

Abstract

STUDY

objectivesManual sleep staging in pediatric populations is challenging due to developmental variability and limited scoring consistency, especially in infants and toddlers. We developed a multimodal deep learning model for pediatric sleep staging and evaluated its performance across a broad age range and diverse clinical subgroups.

methodsWe trained a U-Net-inspired encoder-decoder model (pediatric SleepNet) using 9-channel input signals: electroencephalography (EEG), electrooculography (EOG), and chin electromyography (EMG) using 35-epoch segments from clinical pediatric polysomnograms (PSGs). Models were trained separately on three age groups (<6 months, 6-12 months, >1 year) using 9150 PSGs, with 2455 PSGs reserved for validation. Evaluation was conducted on 3804 held-out test recordings. Performance was compared with U-Sleep and the Complete Artificial Intelligence Sleep Report (CAISR), and stratified analyses were performed across ages, sexes, and seven ICD-10-based disease categories. External validation was conducted on two independent datasets, CHAT and PATS.

resultspediatric SleepNet achieved robust performance across all age groups, with mean Cohen's Kappa increasing from 0.49 (0-6 months) to 0.72 (>12 years). It significantly outperformed U-Sleep and CAISR across early developmental stages. Three-class staging yielded mean Cohen's Kappa increasing from 0.66 (0-6 months) to 0.79 (>12 years). Sex-based differences were negligible. However, significant reductions in performance were observed in children with epilepsy, Down syndrome, hydrocephalus, and other neurodevelopmental conditions. External validation yielded Kappa values >0.69 comparable to the internal test set.

conclusionspediatric SleepNet demonstrates reliable sleep staging across pediatric development. Its robust performance across age, disease, and external datasets supports its potential for clinical and research use in pediatric sleep medicine.

Indexed as

Deep LearningSleep StagesChildChild, PreschoolElectroencephalographyElectromyographyElectrooculographyFemaleHumansInfantMalePolysomnographyautomated scoringdeep learningpediatric sleeppolysomnographysleep staging

Identifiers

PMID41804802
PMCPMC13472892

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.