ArticleEpilepsia2026
Unstable slow oscillations couple with epileptogenic fast-rhythm bistability in sleep-related epilepsy: A stereoelectroencephalographic study.
Article in Epilepsia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Funding
Abstract
objectiveAlthough slow waves in δ (.5-4 Hz) characterize non-rapid eye movement (NREM) sleep, in patients with sleep-related epilepsy, seizures most frequently emerge during NREM stage 2, known to be promoted by δ-band instability. Meanwhile, the epileptogenic zone (EZ) shows localized bistability in β-γ-band (15-200 Hz) neuronal oscillations, indicating a catastrophic shift toward seizure. We aim to clarify the mechanistic link between δ-band synchrony and β-γ-band bistability in epilepsy.
methodsWe studied a cohort of 14 patients with sleep hypermotor epilepsy (22.3 ± 10.8 years old, seven males). Seven- to 9-h stereoelectroencephalographic sleep recordings were segmented into 10-min uninterrupted, interictal N2 and N3 epochs, and phase synchrony, phase-amplitude coupling (PAC), and bistability were assessed. Canonical correlation was examined to answer whether PAC links δ phase to β-γ bistability.
resultsCompared to non-EZ, the EZ exhibited larger 15-200-Hz bistability along with stronger 2-8-Hz and 15-100-Hz synchrony throughout N2 and N3. Compared to N3, N2 showed stronger PAC between 2-30-Hz phases in the non-EZ and 5-150-Hz amplitudes in the EZ. Canonical correlations between δ phase modulated PAC, and both bistability and synchrony were identified during N2 (r = .86 and .82) and N3 (r = .84 and .80), with the strongest contributors being 2-4-Hz synchrony and bistability in 2-4-Hz and 15-200-Hz bands. Correlations between interictal spikes and canonical covariates of bistability and PAC (r SIGNIFICANCE: δ-Band synchrony and β-γ-band bistability are not isolated epileptogenic mechanisms but likely act synergistically, playing a pivotal role in seizure generation through the coupling of δ phases and β-γ amplitudes across large networks, with significant contributions from nonepileptogenic tissues.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.