Observational studyNeurogastroenterology and motility2026
The Role of Functional Lumen Imaging Probe (FLIP) in Addition to High-Resolution Manometry and Timed Barium Esophagram in Treated Achalasia Patients With Persistent or Recurrent Symptoms.
Observational study in Neurogastroenterology and motility, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionA subgroup of treated achalasia patients has recurrent symptoms which prompt consideration of additional treatment. The aim of this study was to examine the additional yield of functional lumen imaging probe (FLIP) to high-resolution manometry (HRM) and timed barium esophagram (TBE) in selection of patients for retreatment.
methodsThis prospective observational cohort study was performed between November 2019 and October 2025 and included treated achalasia patients with recurrent or persistent symptoms who underwent FLIP in addition to HRM and TBE prior to retreatment. The primary outcome was the association between the distensibility index measured by FLIP and response to retreatment (treatment success: Eckardt score ≤ 3).
resultsIn total 84 patients were included (median age 50 years, 36.9% female). At a median follow-up of 11 weeks after retreatment, 82.1% had treatment success (N = 69/84) and 17.9% had treatment failure (N = 15/84). The distensibility index at 40 mL on FLIP did not significantly differ between patients with and without treatment success (1.4 mm
conclusionFLIP did not provide added value over HRM and TBE for identifying treated achalasia patients who may benefit from further treatment. The difficulty in selecting achalasia patients for retreatment highlights the complexity of this patient population and underscores the need for further research.
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