ReviewHistology and histopathology2026
Inverted urothelial papilloma: Diagnostic challenges, molecular insights, and clinical implications.
Review in Histology and histopathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Inverted urothelial papilloma (IUP) is a rare benign tumor of the urinary tract, most commonly arising in the bladder and characterized by an endophytic growth pattern. IUP primarily affects middle-aged and older men and typically presents with painless hematuria. IUP was first described in 1927 and recognized as an independent entity by the World Health Organization in 1973. It can be difficult to distinguish from urothelial carcinoma (UC), which can result in misdiagnosis and overtreatment. Genetic analyses have confirmed the benign nature of IUP. Activating mutations in RAS family genes (
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