Evidence map›Paper›PMID 41804601›Full record

ArticleGM crops & food2026

Engineering glyphosate tolerance in sugarcane through overexpression of a mutated version of its native

Pâmela Ingrid Alves, Talita Heleodoro, Bruno Spinassé Floreste, Daniel Moreira Neris, João Pedro Silvério Pena Bento, Bradley J Smith, Fernanda Mendes de Rezende, Vitor Pinoti, Paulo Cézar de Lucca, Jovanderson Jackson Barbosa da Silva and 6 more

Abstract read
In one paragraph

Article in GM crops & food, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Pâmela Ingrid AlvesLaboratório de Genoma Funcional, Departamento de Genética, Evolução, Microbiologia e Imunologia, Instituto de Biologia, Universidade Estadual de Campinas (UNICAMP), Campinas, Brazil.ORCID 0000-0001-5276-8044
Talita HeleodoroLaboratório de Genoma Funcional, Departamento de Genética, Evolução, Microbiologia e Imunologia, Instituto de Biologia, Universidade Estadual de Campinas (UNICAMP), Campinas, Brazil.ORCID 0000-0002-2288-5765
Bruno Spinassé FloresteLaboratório de Genoma Funcional, Departamento de Genética, Evolução, Microbiologia e Imunologia, Instituto de Biologia, Universidade Estadual de Campinas (UNICAMP), Campinas, Brazil.ORCID 0000-0001-5980-2970
Daniel Moreira NerisLaboratório de Genoma Funcional, Departamento de Genética, Evolução, Microbiologia e Imunologia, Instituto de Biologia, Universidade Estadual de Campinas (UNICAMP), Campinas, Brazil.ORCID 0000-0002-0988-0564
João Pedro Silvério Pena BentoDepartamento de Biologia Vegetal, Instituto de Biologia, Universidade Estadual de Campinas (UNICAMP), Campinas, Brazil.ORCID 0000-0001-7632-3568
Bradley J SmithLaboratório de Neuroproteômica, Departamento de Bioquímica e Biologia Tecidual, Instituto de Biologia, Universidade Estadual de Campinas (UNICAMP), Campinas, Brazil.ORCID 0000-0003-1383-5851
Fernanda Mendes de RezendeLaboratório de Fisiologia Ecológica de Plantas (LAFIECO), Departamento de Botânica, Instituto de Biociências, Universidade de São Paulo (USP), São Paulo, Brazil.ORCID 0000-0002-0570-4555
Vitor PinotiLaboratório de Genoma Funcional, Departamento de Genética, Evolução, Microbiologia e Imunologia, Instituto de Biologia, Universidade Estadual de Campinas (UNICAMP), Campinas, Brazil.ORCID 0000-0002-7715-5233
Paulo Cézar de LuccaLaboratório de Genoma Funcional, Departamento de Genética, Evolução, Microbiologia e Imunologia, Instituto de Biologia, Universidade Estadual de Campinas (UNICAMP), Campinas, Brazil.ORCID 0000-0001-6492-3515
Jovanderson Jackson Barbosa da SilvaLaboratório de Genômica e bioEnergia, Departamento de Genética, Evolução, Microbiologia e Imunologia, Instituto de Biologia, Universidade Estadual de Campinas (UNICAMP), Campinas, Brazil.ORCID 0000-0002-9601-6415
Marcelo Falsarella CarazzolleLaboratório de Genômica e bioEnergia, Departamento de Genética, Evolução, Microbiologia e Imunologia, Instituto de Biologia, Universidade Estadual de Campinas (UNICAMP), Campinas, Brazil.ORCID 0000-0002-5474-2830
Gonçalo Amarante Guimarães PereiraLaboratório de Genômica e bioEnergia, Departamento de Genética, Evolução, Microbiologia e Imunologia, Instituto de Biologia, Universidade Estadual de Campinas (UNICAMP), Campinas, Brazil.ORCID 0000-0003-4140-3482
Paulo MazzaferaDepartamento de Biologia Vegetal, Instituto de Biologia, Universidade Estadual de Campinas (UNICAMP), Campinas, Brazil.ORCID 0000-0001-9073-4056
Juliana Lischka Sampaio MayerDepartamento de Biologia Vegetal, Instituto de Biologia, Universidade Estadual de Campinas (UNICAMP), Campinas, Brazil.ORCID 0000-0001-7439-5234
Marcos Silveira BuckeridgeLaboratório de Fisiologia Ecológica de Plantas (LAFIECO), Departamento de Botânica, Instituto de Biociências, Universidade de São Paulo (USP), São Paulo, Brazil.ORCID 0000-0002-5455-8136
Marcelo MenossiLaboratório de Genoma Funcional, Departamento de Genética, Evolução, Microbiologia e Imunologia, Instituto de Biologia, Universidade Estadual de Campinas (UNICAMP), Campinas, Brazil.ORCID 0000-0002-9211-3787

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sugarcane is a globally important crop, widely used in both the food industry and biofuel production. Weed infestations can significantly reduce its productivity, and to address this challenge, herbicides such as glyphosate are commonly applied. Glyphosate acts as a structural analog of phosphoenolpyruvate (PEP), inhibiting the enzyme 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS), thereby disrupting the shikimate pathway and impairing the biosynthesis of essential aromatic amino acids required for plant growth and development. However, the limited tolerance of sugarcane to glyphosate restricts herbicide application to doses that are often insufficient for effective weed control. Previous studies have shown that amino acid substitutions in the EPSPS enzyme, particularly the T102I/P106A (TIPA) mutations, can confer glyphosate resistance in plants. In this study, we evaluated whether a specific mutation in the endogenous

Indexed as

3-Phosphoshikimate 1-CarboxyvinyltransferaseGlycineHerbicide ResistanceHerbicidesSaccharumGlyphosateMutationPlants, Genetically Modified3-Phosphoshikimate 1-CarboxyvinyltransferaseGlycineGlyphosateHerbicidesHerbicide toleranceSaccharumsite-directed mutation

Identifiers

PMID41804601
PMCPMC12977275

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.