Trial reportInternational journal of rheumatic diseases2026
Can a Targeted Pre-Exercise Education Intervention Enhance the Exercise-Induced Hypoalgesia (EIH) Response in Individuals With Knee Osteoarthritis (OA)?
Trial report in International journal of rheumatic diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Letter to the Editor Regarding: "Can a Targeted Pre-Exercise Education Intervention Enhance the Exercise-Induced Hypoalgesia (EIH) Response in Individuals With Knee Osteoarthritis (OA)?"International journal of rheumatic diseases · 2026Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveRecent evidence suggests that education on the pain-relieving effects of exercise may enhance exercise-induced hypoalgesia (EIH) in healthy individuals. However, its impact in populations with osteoarthritis (OA), where EIH responses are more variable, remains unclear. This study examined whether positive pre-exercise education enhances EIH in individuals with knee OA.
methodsA double-blind, randomized controlled trial was conducted with 42 participants allocated to either a positive pre-exercise education group (n = 21) or a control education group (n = 21). Each group received two individual education sessions 24-72 h apart. OA- and EIH-related knowledge and beliefs were assessed pre- and post-education. EIH was evaluated following a single submaximal isometric quadriceps contraction to failure by measuring changes in pressure pain thresholds (PPTs), resting pain, and pain during stepping. Group differences were analyzed using ANCOVA.
resultsThe positive pre-exercise education group demonstrated greater improvements in EIH-related knowledge and beliefs compared to the control group (p = 0.001, d = 0.50, ANCOVA between-group analysis), while OA-related knowledge and beliefs remained unchanged (p = 0.34, d = 0.15). However, ANCOVA results showed no significant between-group differences in pre- to post-exercise changes in PPTs, resting pain, or pain during stepping (all p > 0.11, d = 0.04-0.25).
conclusionDespite enhancing beliefs about exercise-induced pain relief, positive pre-exercise education did not enhance EIH compared to control education. These findings highlight the need for alternative strategies to optimize exercise-induced pain relief in OA.
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