Evidence map›Paper›PMID 41804375›Full record

ArticleInternational journal of general medicine2026

The Value of Cord Blood CXCL10 and MMP8 as Biomarkers in Predicting Bronchopulmonary Dysplasia- A Retrospective Cohort Study.

Xian He, Xuemin Qie, Huanhuan Ma, Weina Li, Jiahui Li, Xin He

Abstract read
In one paragraph

Article in International journal of general medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xian HeDepartment of Neonatology, Baoding Maternal and Child Health Hospital, Baoding, Hebei Province, People's Republic of China.
Xuemin QieDepartment of Neonatology, Baoding Maternal and Child Health Hospital, Baoding, Hebei Province, People's Republic of China.
Huanhuan MaDepartment of Neonatology, Baoding Maternal and Child Health Hospital, Baoding, Hebei Province, People's Republic of China.
Weina LiDepartment of Neonatology, Baoding Maternal and Child Health Hospital, Baoding, Hebei Province, People's Republic of China.
Jiahui LiSchool of Nursing, Peking University, Beijing, People's Republic of China.
Xin HeDepartment of neonatology, Baoding No.1 Central Hospital, Baoding, Hebei Province, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To evaluate whether cord blood C-X-C motif chemokine ligand 10 (CXCL10) and Matrix Metalloproteinase 8 (MMP8) predict bronchopulmonary dysplasia (BPD) in preterm infants. Methods: In this retrospective cohort study (January 2019-December 2023), we enrolled 272 preterm infants (22-32 weeks' gestation; birth weight 631-1493 g) admitted to Baoding Maternal and Child Health Hospital. Mean gestational age was 27.31 ± 1.97 weeks and mean birth weight 1,166.44 ± 245.63 g. Neonates were classified into BPD (n = 90) and non-BPD (n = 182) groups. Cord-blood CXCL10 and MMP-8 were quantified by enzyme-linked immunosorbent assay (ELISA). Associations were evaluated using Spearman correlation, multivariable logistic regression, and receiver operating characteristic (ROC) curve analysis. Results: Infants who developed BPD had lower birth weight and Apgar scores at 1 and 5 minutes, and were more likely to be born at < 28 weeks' gestation, to have neonatal respiratory distress syndrome (NRDS), to require FiO Conclusion: Elevated cord blood CXCL10 and MMP8 levels are strongly associated with BPD development. Their combined measurement may help identify preterm infants at risk, although external validation is warranted.

Indexed as

bronchopulmonary dysplasiaclinical valuecord bloodC-X-C motif chemokine ligand 10matrix metalloproteinase 8preterm infants

Identifiers

PMID41804375
PMCPMC12967426

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