ArticleNature and science of sleep2026
Changed Serum Levels of Sirtuin1 and Sirtuin3 and Their Correlations with Sleep Quality and Cognitive Function in Patients with Chronic Insomnia Disorder.
Article in Nature and science of sleep, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- The mitochondrial theory of sleep: an integrative framework for understanding sleep-wake regulation.Frontiers in psychiatry · 2026Review
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: The purpose of this study is to investigate the relationship between the serum concentrations of the mitochondrial markers sirtuins-1 and sirtuins-3, sleep quality and cognitive function in individuals with chronic insomnia disorder (CID). Patients and Methods: A cohort of 80 patients with CID and 42 healthy controls (HCs) were recruited for the study. Serum concentrations of SIRT1 and SIRT3 were quantified using enzyme-linked immunosorbent assays. Sleep quality was evaluated utilizing the Pittsburgh Sleep Quality Index (PSQI) and polysomnography. The cognitive assessment tools employed included the Chinese version of the Montreal Cognitive Assessment (MoCA-C) for evaluating overall cognitive function, the Nine Box Maze Test (NBMT) for assessing multidimensional memory, and the Blue Velvet Arena Test (BVAT) for examining spatial memory. Results: In comparison to HCs, patients with CID exhibited a significantly elevated PSQI score (Z=-9.094, Conclusion: Patients with CID may have mitochondrial dysfunction in the brain which might be associated with worse sleep and cognition.
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