ArticleIJU case reports2026
Apalutamide-Induced Hypothyroidism Associated With Increased Thyroid Hormone Clearance in Metastatic Prostate Cancer Patient: A Case Report.
Article in IJU case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Apalutamide (APA) is an androgen receptor signaling inhibitor widely used for metastatic hormone-sensitive prostate cancer (mHSPC), though it can induce hypothyroidism. We report a severe case of APA-induced hypothyroidism in a patient with a history of total thyroidectomy. Case Presentation: A 65-year-old man receiving levothyroxine (175 μg/day) after thyroidectomy was diagnosed with mHSPC (Gleason score 4 + 4; PSA 13 904 ng/mL) with findings suggestive of cancer-associated disseminated intravascular coagulation. Following APA initiation (240 mg/day), PSA decreased rapidly to 0.01 ng/mL. However, TSH levels rose progressively despite increasing levothyroxine to 275 μg/day. After a 4-month follow-up interruption, TSH reached 187.9 mIU/L. APA withdrawal led to rapid TSH improvement. Conclusion: Careful TSH monitoring is essential during APA treatment, especially in patients with pre-existing thyroid dysfunction or prior thyroidectomy. Appropriate levothyroxine titration and multidisciplinary collaboration are essential for the continuation of oncological therapy with APA.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.