ReviewOrthopedic research and reviews2026
Research Progress on the Evaluation and Clinical Value of Negative Surgical Margins in Osteosarcoma.
Review in Orthopedic research and reviews, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Achieving negative surgical margins is a critical objective in osteosarcoma management, directly linked to reduced local recurrence and improved survival. This review comprehensively examines the evaluation techniques and clinical significance of these margins. We discuss the ongoing debate surrounding the optimal margin width and the impact of neoadjuvant chemotherapy on this standard. The application of conventional imaging (X-ray, CT, MRI) and advanced technologies (radiomics, fluorescence imaging, robot-assisted surgery) for margin assessment is analyzed. Furthermore, we explore treatment strategies to secure negative margins. By synthesizing current evidence, this article aims to guide clinicians in margin selection and highlights future directions for improving oncological outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.