Evidence map›Paper›PMID 41804279›Full record

ArticleJournal of women's health (2002)2026

Use of Chemical Hair Straighteners and Menstrual Disturbances.

Ruth J Geller, Samantha Schildroth, Nyia L Noel, Tamarra James-Todd, Donna D Baird, Lauren A Wise, Amelia K Wesselink

Abstract read
In one paragraph

Article in Journal of women's health (2002), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ruth J GellerDepartment of Epidemiology, Boston University School of Public Health, Boston, Massachusetts, USA.
Samantha SchildrothDepartment of Epidemiology, Boston University School of Public Health, Boston, Massachusetts, USA.
Nyia L NoelDepartment of Obstetrics and Gynecology, Boston University Chobanian and Avedisian School of Medicine, Boston Medical Center, Boston, Massachusetts, USA.
Tamarra James-ToddDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
Donna D BairdEpidemiology Branch, National Institute of Environmental Health Sciences, Durham, North Carolina, USA.
Lauren A WiseDepartment of Epidemiology, Boston University School of Public Health, Boston, Massachusetts, USA.
Amelia K WesselinkDepartment of Epidemiology, Boston University School of Public Health, Boston, Massachusetts, USA.

Funding

An internet-based preconception cohort study in North America and DenmarkR01HD086742 · NICHD · BOSTON UNIVERSITY MEDICAL CAMPUS · PI LAUREN A WISE · 2016 to 2026
$6.7M
A preconception cohort study of air pollution, fertility, and miscarriageR01ES028923 · NIEHS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI LAUREN A WISE, Amelia Kent Wesselink · 2018 to 2026
$4.3M
A preconception cohort study of environmental chemicals, fertility, and miscarriageR01ES029951 · NIEHS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI WISE, LAUREN A · 2019 to 2023
$3.1M
Phthalates, Gestational Diabetes, and Markers of Type 2 Diabetes Risk in WomenR01ES026166 · NIEHS · HARVARD SCHOOL OF PUBLIC HEALTH · PI JAMES-TODD, TAMARRA M · 2016 to 2021
$2.9M
NICHD NIH HHS R01 HD086742NIEHS NIH HHS R01 ES026166NIEHS NIH HHS R01 ES028923NIEHS NIH HHS R01 ES029951
6 · The paper itself

Abstract

backgroundUse of chemical hair straighteners ("relaxers") is associated with higher risks of hormonally mediated conditions. We hypothesized users of relaxers would have a higher prevalence of abnormal uterine bleeding (AUB) and dysmenorrhea. MATERIALS AND

methodsWe analyzed baseline data from Pregnancy Study Online, an internet-based preconception cohort study of North American pregnancy planners. We included 14,366 participants aged 21-39 years who enrolled during 2014-2024 and reported on their typical menstrual cycle characteristics when not using hormones. We collected data on history of use, age at first use, frequency per year, duration of use, and number of burns. We defined AUB as cycle length <24 or >38 days, flow ≥ 7 days, irregular cycles, and/or heavy flow (>30 pads/tampons per menses). We defined dysmenorrhea as severe cramps requiring medication and bed rest. We used modified Poisson regression models to estimate prevalence ratios (PRs) and 95% confidence intervals (CIs) for the associations of relaxer use with AUB and dysmenorrhea, adjusted for potential confounders.

resultsOverall, 2% of participants were current users and 10% were former users of relaxers. The frequencies of AUB and dysmenorrhea were 31% and 8%, respectively. PRs for current (versus never) relaxer use were 1.16 (95% CI: 1.00-1.33) for AUB and 1.30 (95% CI: 0.94-1.80) for dysmenorrhea. Participants who reported ever experiencing burns (versus never use) had a higher prevalence of dysmenorrhea (1-4 burns: PR = 1.42, 95% CI: 1.04-1.93; ≥5 burns: PR = 1.46, 95% CI: 1.00-2.13).

conclusionRelaxer use was associated with a higher prevalence of menstrual disturbances.

Indexed as

DysmenorrheaHair PreparationsMenstruation DisturbancesUterine HemorrhageAdultCohort StudiesFemaleHumansPrevalenceYoung AdultHair Preparationschemical straightenersdysmenorrheaepidemiologyhair productsmenstruation disturbancespersonal care products

Identifiers

PMID41804279
PMCPMC13535589

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.