ArticleLiver international : official journal of the International Association for the Study of the Liver2026
Longitudinal, Multicenter Study of Clinical Factors Impacting Health-Related Quality of Life in Paediatric Autoimmune Liver Disease.
Article in Liver international : official journal of the International Association for the Study of the Liver, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Not yet cited in PubMed.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Longitudinal Study for the Assessment of MRI Based Biomarkers as a Predictors of Clinical Endpoints in Pediatric Onset Autoimmune Liver Disease
Autoimmune Liver Disease Network for Kids (A-LiNK): Using Patient Data to Transform Care and Improve Outcomes for Children, Adolescents, and Young Adults With Autoimmune Liver Disease
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Abstract
backgroundChildren with autoimmune liver disease (AILD) face unique challenges that may impair their health-related quality of life (HRQoL). This multicenter, prospective, longitudinal study evaluated HRQoL over time and identified associated clinical factors.
methodsA total of 162 participants from five centers completed at least one HRQoL assessment. Medical and laboratory data were abstracted within 3 months of each assessment. Fatigue and pruritus were reported at one center. Generalised linear mixed-effects modelling was used to examine longitudinal associations between HRQoL and clinical variables.
resultsParticipants reported the lowest HRQoL scores in school and emotional domains, while the physical and social domains were less affected. Compared to healthy children, participants with AILD reported lower overall HRQoL. Longitudinal analysis revealed that caregivers of participants with overlap syndrome reported higher emotional, social, psychosocial, and total scores. Across all AILD subtypes, children with AILD-complications reported higher school scores. Prednisone use was associated with improved emotional scores, while azathioprine use was associated with lower social scores. Elevated alanine aminotransferase levels were associated with lower HRQoL scores, particularly in caregiver reports. Disease duration and presence of inflammatory bowel disease were not associated with HRQoL. In a single center subset, fatigue and pruritus were associated with lower HRQoL, and fatigue correlated with elevated liver enzymes and reduced rates of biochemical remission.
conclusionThese findings highlight overall AILD-related patterns in HRQoL rather than disease-specific effects and underscore the multidimensional impact of AILD. Studies with disease-specific cohorts and validated symptom instruments are needed to clarify subtype-specific mechanisms, particularly those related to fatigue.
trial registrationNCT03178630, NCT05750498.
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