ReviewThe Australasian journal of dermatology2026
Efficacy of Biologics for Hidradenitis Suppurativa: A Network Meta Analysis and Meta Regression for Baseline Disease Severity.
Review in The Australasian journal of dermatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
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Authors and funding
7 authors.
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Abstract
Hidradenitis Suppurativa is a challenging, heterogeneous inflammatory skin disease, with three approved biologic therapies. No head-to-head studies exist comparing these therapeutic modalities, and previous work has identified the influence of baseline disease severity upon clinical response. We aimed to perform a network meta-analysis of approved biologic therapies and meta-regression of baseline disease severity in moderate to severe HS. Pubmed, Embase, and Web of Science were searched from their inception up until 31 July 2025. Randomised Phase 3 clinical trials of biologic therapies approved for use in moderate to severe Hidradenitis Suppurativa. Network meta-analysis was conducted via both frequentist and Bayesian frameworks. Subgroup analysis was performed using a priori identified covariates (baseline AN count, tunnel count, BMI, and smoking), and random effects meta regression was performed with the final model selected using restricted maximum likelihood, I
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