Evidence map›Paper›PMID 41804082›Full record

ArticleEuropean journal of oral sciences2026

Physicochemical and remineralisation properties of calcium silicate and glass ionomer cements applied in simulated caries-affected dentine.

Monika Lukomska-Szymanska, Mateusz Radwanski, Stella Helen Constantinidou, Augusto R Elias Boneta, Umer Daood, Kharouf Naji, Filippo Cardinali, Salvatore Sauro

Abstract read
In one paragraph

Article in European journal of oral sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Monika Lukomska-SzymanskaDepartment of General Dentistry, Medical University of Lodz, Lodz, Poland.ORCID 0000-0002-6110-4298
Mateusz RadwanskiDepartment of Endodontics, Medical University of Lodz, Lodz, Poland.ORCID 0000-0003-2333-0996
Stella Helen ConstantinidouDental Biomaterials and Minimally Invasive Dentistry, Departamento de Odontología, Facultad de Ciencias de la Salud, Universidad CEU-Cardenal Herrera, Alfara del Patriarca, Valencia, Spain.ORCID 0009-0007-1150-2363
Augusto R Elias BonetaSchool of Dental Medicine, University of Puerto Rico, San Juan, Puerto Rico.ORCID 0000-0003-0789-9429
Umer DaoodRestorative Dentistry Division, School of Dentistry, IMU, Kuala Lumpur, Malaysia.ORCID 0000-0002-7631-1628
Kharouf NajiDepartment of Biomaterials and Bioengineering, INSERM UMR_S 1121, Strasbourg University, Strasbourg, France.ORCID 0000-0001-6768-138X
Filippo CardinaliDental Biomaterials and Minimally Invasive Dentistry, Departamento de Odontología, Facultad de Ciencias de la Salud, Universidad CEU-Cardenal Herrera, Alfara del Patriarca, Valencia, Spain.ORCID 0009-0001-6426-7121
Salvatore SauroDental Biomaterials and Minimally Invasive Dentistry, Departamento de Odontología, Facultad de Ciencias de la Salud, Universidad CEU-Cardenal Herrera, Alfara del Patriarca, Valencia, Spain.ORCID 0000-0002-2527-8776

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Calcium silicate-based and glass ionomer cements are often used in caries-affected dentine. This study investigated the remineralising and physicochemical properties of two calcium silicates and a glass ionomer cement. Human molars with Class I cavities were subjected to pH cycling to simulate caries lesions. These were restored using two different calcium silicate cements (CTR-MTA or MTA-VOCO) or a glass ionomer cement (GIC). After storage in artificial saliva, Knoop microhardness (KHN) was measured within a 300-µm zone from the interface. Solubility, pH, calcium ion release, scanning electron microscopy (SEM)-energy-dispersive x-ray (EDX) and Fourier-transform infrared spectroscopy (FTIR) analyses were also conducted. Data were statistically analysed with statistical significance set at p < 0.05. Both MTAs promoted greater remineralisation (KHN) compared to GIC. GIC showed the lowest solubility, whereas CTR-MTA demonstrated the highest solubility, followed by MTA-VOCO; the latter had the highest calcium release. Apatite deposition was observed only in the MTA groups (SEM-EDX and FTIR). MTA-VOCO demonstrated superior calcium ion release and increased dentine microhardness, although some signs of collagen degradation were also visible. Clinical relevance: GIC and calcium silicate cements may enhance mineral deposition in caries-affected dentine, though the alkalinity of MTAs might compromise collagen integrity at the bonding interface.

Indexed as

Calcium CompoundsDental CariesDentinGlass Ionomer CementsSilicatesTooth RemineralizationAluminum CompoundsCalciumDrug CombinationsHardnessHumansHydrogen-Ion ConcentrationMaterials TestingMicroscopy, Electron, ScanningOxidesSaliva, ArtificialAluminum CompoundsCalciumCalcium Compoundscalcium silicateDrug CombinationsGlass Ionomer Cementsmineral trioxide aggregateOxidesSaliva, ArtificialSilicatescalcium ionsdegradationdentine collagenmicrohardnessmineral trioxide aggregatesolubility

Identifiers

PMID41804082
PMCPMC13181527

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.