Observational studyAnnals of transplantation2026
Outcomes of Liver Transplantation Without Alcohol Abstinence in Alcohol-Associated Hepatitis With Original MELD Score ≥30.
Observational study in Annals of transplantation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Clinical outcomes of early versus standard liver transplantation in patients with alcohol-related liver disease: a meta-analysis.Langenbeck's archives of surgery · 2026Pooled it
- Blaming the Patient: The Ethical Failures of Responsibility-Based Liver Transplant Policy in Alcohol Use Disorder.Bioethics · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND Achieving alcohol abstinence before standard liver transplantation (SLT) for alcohol-associated liver disease (ALD) is commonly accepted. However, the 3-month mortality rate for alcohol-associated hepatitis (AH) patients with extremely high Model for End-Stage Liver Disease (MELD) scores (≥30) exceeds 50%, suggesting insufficient time for these patients to achieve sobriety. Current data on outcomes for non-abstinent individuals in this high-risk group undergoing early liver transplantation (ELT) is limited. MATERIAL AND METHODS This single-center observational study (May 2002 to October 2023) involved 1410 liver transplantation (LT) patients. After excluding those with a MELD score <30 (n=1178), no alcohol use (n=166), hepatocellular carcinoma (n=7), viral hepatitis (n=24), and other liver failure (n=1), 34 recipients with ALD were identified. Patients were divided into Group A (abstinence prior to transplant) and Group NA (non-abstinence prior to transplant) based on pre-transplant drinking status, with clinical factors and long-term outcomes compared. RESULTS Among LT recipients who had AH, 94.1% (n=32) were male, with a median daily alcohol consumption of 174 grams and a drinking history of 20 years. Group A had 12 abstinent recipients, 6 of whom maintained sobriety for over 6 months before LT. Long-term survival rates were similar between Group NA and Group A (1, 3, and 5 years after transplant: 75.3%, 69.5%, and 52.1% vs 83.3%, 58.3%, and 48.6%; P=0.908). CONCLUSIONS Pre-transplant alcohol abstinence did not correlate with improved survival in severe AH patients, suggesting that such patients should not be disqualified from LT based solely on alcohol history.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.