Evidence map›Paper›PMID 41804056›Full record

ArticleJournal of neuroimaging : official journal of the American Society of Neuroimaging

Quantitative Choroid Plexus Gadolinium Enhancement Is Related to Diffuse Brain Tissue Injury in Multiple Sclerosis.

Sneha Senthil, Ian Tagge, Dumitru Fetco, Cheng Hsun Hsieh, Haz-Edine Assemlal, Zahra Karimaghaloo, Emily Fetco, G R Wayne Moore, Douglas L Arnold, David A Rudko and 1 more

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In one paragraph

Article in Journal of neuroimaging : official journal of the American Society of Neuroimaging. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Sneha SenthilMcConnell Brain Imaging Centre, Montreal Neurological Institute-Hospital, McGill University, Montreal, Quebec, Canada.ORCID https://orcid.org/0000-0002-3601-9497
Ian TaggeMcConnell Brain Imaging Centre, Montreal Neurological Institute-Hospital, McGill University, Montreal, Quebec, Canada.
Dumitru FetcoMcConnell Brain Imaging Centre, Montreal Neurological Institute-Hospital, McGill University, Montreal, Quebec, Canada.
Cheng Hsun HsiehMcConnell Brain Imaging Centre, Montreal Neurological Institute-Hospital, McGill University, Montreal, Quebec, Canada.
Haz-Edine AssemlalMcConnell Brain Imaging Centre, Montreal Neurological Institute-Hospital, McGill University, Montreal, Quebec, Canada.
Zahra KarimaghalooMcConnell Brain Imaging Centre, Montreal Neurological Institute-Hospital, McGill University, Montreal, Quebec, Canada.
Emily FetcoNeuroRx Research, Montreal, Quebec, Canada.
G R Wayne MooreDepartment of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada.
Douglas L ArnoldMcConnell Brain Imaging Centre, Montreal Neurological Institute-Hospital, McGill University, Montreal, Quebec, Canada.
David A RudkoMcConnell Brain Imaging Centre, Montreal Neurological Institute-Hospital, McGill University, Montreal, Quebec, Canada.
Sridar NarayananMcConnell Brain Imaging Centre, Montreal Neurological Institute-Hospital, McGill University, Montreal, Quebec, Canada.

Funding

CIHR 153005from Novartis CanadaU.S. Department of Defense W81XWH19-1-0486
6 · The paper itself

Abstract

backgroundRecent studies suggest that disruptions of the blood-cerebrospinal fluid (CSF) barrier within the choroid plexus (ChP) may contribute to multiple sclerosis (MS) pathogenesis. We investigated the relationship between a quantitative marker of ChP enhancement and markers of focal and diffuse brain tissue injury in MS.

methodsA group of 34 MS participants and 21 healthy participants underwent 7T MRI including magnetization prepared 2 rapid acquisition gradient echoes (MP2RAGE) and fluid attenuated inversion recovery (FLAIR) acquisitions. The MS group received contrast, and delta T1 (ΔT1) maps were computed to assess enhancement. ChP, white matter lesions (WML), normal-appearing white matter (NAWM), and gray matter (GM) were segmented. Pre-contrast quantitative T1 (qT1) values were compared between groups, and linear regression with mean ChP ΔT1 was performed for WML volume and pre-gadolinium (Gd) mean qT1 of WML, NAWM, and GM.

resultsMean qT1 of ChP, NAWM, and GM, as well as ChP volume, were higher in MS compared to controls (p < 0.001). ChP ΔT1 was significantly associated with pre-Gd qT1 of NAWM (β = 0.20, R

conclusionsThe association between ChP enhancement and diffuse tissue injury, together with elevated qT1 values and ChP volumes in MS, supports a mechanism of brain injury involving CSF-mediated toxicity distinct from classic lesion pathology in MS.

Indexed as

Brain InjuriesChoroid PlexusMagnetic Resonance ImagingMultiple SclerosisAdultContrast MediaFemaleHumansMaleMiddle AgedContrast Mediablood–CSF barrierchoroid plexustissue damage

Identifiers

PMID41804056
PMCPMC12972605

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.