Evidence map›Paper›PMID 41803903›Full record

ArticleMolecular brain2026

Shank3B deficiency disrupts GABAergic synaptic transmission in pyramidal neurons of the medial prefrontal cortex region in autism spectrum disorder.

Heqing Yin, Ke Sun, Chenyang Wang, Songqiao Fan, Jiaqi Wang, Shitai He, Hui Meng Lei, Shuo Pang, Jun Chen, Guojun Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular brain, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Heqing YinThe Laboratory of Neurological Disorders and Brain Cognition, National Center for Children's Health, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, Beijing, 100045, China.
Ke SunThe Laboratory of Neurological Disorders and Brain Cognition, National Center for Children's Health, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, Beijing, 100045, China.
Chenyang WangThe Laboratory of Neurological Disorders and Brain Cognition, National Center for Children's Health, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, Beijing, 100045, China.
Songqiao FanThe Laboratory of Neurological Disorders and Brain Cognition, National Center for Children's Health, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, Beijing, 100045, China.
Jiaqi WangThe Laboratory of Neurological Disorders and Brain Cognition, National Center for Children's Health, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, Beijing, 100045, China.
Shitai HeThe Laboratory of Neurological Disorders and Brain Cognition, National Center for Children's Health, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, Beijing, 100045, China.
Hui Meng LeiLaboratory for Clinical Medicine, Beijing Key Laboratory of Neural Regeneration and Repair, Key Laboratory for Neurodegenerative Diseases of the Ministry of Education, Department of Neurobiology, School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, China.
Shuo PangThe Laboratory of Neurological Disorders and Brain Cognition, National Center for Children's Health, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, Beijing, 100045, China. pangshuo@mail.ccmu.edu.cn.
Jun ChenThe Laboratory of Neurological Disorders and Brain Cognition, National Center for Children's Health, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, Beijing, 100045, China. chenjun@bch.com.cn.
Guojun ZhangThe Laboratory of Neurological Disorders and Brain Cognition, National Center for Children's Health, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, Beijing, 100045, China. zgjxwyy@126.com.

Funding

Beijing Science and Technology Commission: AI+ Health Collaborative Innovation Cultivation Z221100003522017Funding for Reform and Development of Beijing Municipal Health Commission EYGF-SJ-09Joint Basic-Clinical Laboratory of Pediatric Epilepsy and Cognitive Developmental 3-1-013-03National Natural Science Foundation of China 82401383Natural Science Foundation of Beijing Municipality 7244343
6 · The paper itself

Abstract

Mutations in the SHANK3B gene have been strongly implicated in the pathogenesis of autism spectrum disorder (ASD). The medial prefrontal cortex (mPFC) is integral to emotional processing and social behavior, and its atypical development is closely associated with ASD pathogenesis. However, the electrophysiological characteristics of pyramidal neurons within the mPFC and the mechanisms of their synaptic transmission remain inadequately characterized. In the present study, we conducted whole-cell patch-clamp recordings on mPFC pyramidal neurons in Shank3b knockout mice. We observed significant alterations in the membrane properties and excitability of mPFC pyramidal neurons in Shank3b knockout mice; these were accompanied by reduced inhibitory postsynaptic currents and deficiencies in γ-aminobutyric acid (GABA) release or GABA

Indexed as

Autism Spectrum DisorderGABAergic Neuronsgamma-Aminobutyric AcidNerve Tissue ProteinsPrefrontal CortexPyramidal CellsSynaptic TransmissionAnimalsGene Expression RegulationMaleMice, Inbred C57BLMice, KnockoutReceptors, GABA-ASynapsesgamma-Aminobutyric AcidNerve Tissue ProteinsReceptors, GABA-AAutism spectrum disorderGABAergic synaptic transmissionMedial prefrontal cortexShank3b knockout miceSynapse

Identifiers

PMID41803903
PMCPMC13069784

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.