Evidence map›Paper›PMID 41803881›Full record

ReviewJournal of translational medicine2026

Sphingolipids in human disease: organ-specific pathologies, chain-length-dependent effects, and translational implications.

Lili Kong, Jiaxin Shi, Siyuan Wang, Jiaqi Huang, Yidong Ge, Yvxuan Li, KaiLang Li, Mengxiang Zhao, Zhiyou Li, Xiaofeng Jin

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of translational medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Lili KongDepartment of Biochemistry and Molecular Biology, Health Science Center, Ningbo University, Ningbo, Zhejiang, China.
Jiaxin ShiDepartment of Biochemistry and Molecular Biology, Health Science Center, Ningbo University, Ningbo, Zhejiang, China.
Siyuan WangDepartment of Biochemistry and Molecular Biology, Health Science Center, Ningbo University, Ningbo, Zhejiang, China.
Jiaqi HuangDepartment of Biochemistry and Molecular Biology, Health Science Center, Ningbo University, Ningbo, Zhejiang, China.
Yidong GeDepartment of Biochemistry and Molecular Biology, Health Science Center, Ningbo University, Ningbo, Zhejiang, China.
Yvxuan LiDepartment of Biochemistry and Molecular Biology, Health Science Center, Ningbo University, Ningbo, Zhejiang, China.
KaiLang LiDepartment of Oncology, Beilun Branch of the First Affiliated Hospital, College of Medicine, Zhejiang University, Ningbo, 315826, China.
Mengxiang ZhaoDepartment of Stomatology, The First Affiliated Hospital of Ningbo University, Ningbo University, Ningbo, Zhejiang, China.
Zhiyou LiDepartment of Biochemistry and Molecular Biology, Health Science Center, Ningbo University, Ningbo, Zhejiang, China.
Xiaofeng JinDepartment of Biochemistry and Molecular Biology, Health Science Center, Ningbo University, Ningbo, Zhejiang, China. jinxiaofeng@nbu.edu.cn.ORCID 0000-0003-0801-8638

Funding

National Natural Science Foundation of China 32270821National Natural Science Foundation of China Nos. 32570835National Natural Science Foundation of China Nos. 82303320Natural Science Foundation of Ningbo No. 2024J037Natural Science Foundation of Ningbo No. 2024J345Natural Science Foundation of Zhejiang Province No. LY24C050001Ningbo University 2025 graduate research innovation project IF2025055Ningbo University 2025 graduate research innovation project IF2025058Ningbo University Student Research and Innovation Program 2025SRIP1922Zhejiang Provincial Natural Science Foundation of China ZCLQ24H1603
6 · The paper itself

Abstract

backgroundSphingolipids, particularly ceramide (Cer) and sphingomyelin (SM), are critical for cellular homeostasis, serving as both essential membrane components and key signaling molecules. This review systematically classifies sphingolipid disorders by organ system, emphasizing chain-length-dependent effects such as the pro-inflammatory role of C16-Cer versus the protective functions of C24-Cer in disease. MAIN BODY: The review details sphingolipid involvement across seven major organ systems. In cardiovascular disease, SM(d18:1/16:1) contributes to atherosclerotic plaque instability, while Cer promotes NLRP3 inflammasome activation. In neurodegenerative diseases, an altered Cer/SM ratio disrupts lipid raft integrity and accelerates pathogenic protein aggregation. In oncology, cancer progression is facilitated through mechanisms like nSMase-mediated exosome release and CerS6-dependent metastasis. Translational applications are emerging, including Cer-based biomarkers with high diagnostic accuracy for early stroke and investigational aSMase inhibitors for atherosclerosis.

conclusionModulating sphingolipid metabolism presents a promising therapeutic strategy for precision medicine. However, challenges remain in deciphering tissue-specific regulatory networks and standardizing lipidomic methodologies.

Indexed as

DiseaseOrgan SpecificitySphingolipidsTranslational Research, BiomedicalTranslational Science, BiomedicalAnimalsHumansSphingolipidsCancersCeramideNeurodegenerative diseasesSphingolipid metabolismSphingomyelin

Identifiers

PMID41803881
PMCPMC13085703

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.