ArticleRadiation oncology (London, England)2026
Assessing respiratory motion effects after breathing training on hybrid and IMRT plans in hypofractionated breast radiotherapy.
Article in Radiation oncology (London, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThis study aimed to evaluate the dosimetric impact of respiratory motion after breathing training on Hybrid and IMRT plans in hypofractionated breast radiotherapy, using 4D-CT and deformable dose accumulation.
methodsTwenty-two postoperative breast cancer patients treated under free breathing underwent both 3D-CT and 4D-CT scanning after abdominal breathing training. Original Hybrid (O_HY) and IMRT (O_IM) plans were generated on 3D-CT. Each plan was mapped onto the ten 4D-CT phases and recalculated. Deformable image registration was applied to accumulate phase-specific doses onto the original 3D-CT, generating motion-inclusive deformed Hybrid (D_HY) and IMRT (D_IM) plans. Respiratory motion amplitudes of the chest wall and liver were quantified. Dosimetric parameters of targets and OARs were evaluated and compared.
resultsAfter breathing training, respiratory motion amplitudes were 13.2 ± 4.6 mm for the liver and 1.54 ± 0.85 mm for the chest wall. Both techniques achieved good target coverage in the original plans, with comparable hotspot, homogeneity, and conformity. Hybrid plans provided superior OAR sparing, particularly in the low-dose regions. After deformable dose accumulation, target coverage exhibited only minor decreases: PTV_V100% decreased by 2.5% for Hybrid and 2.1% for IMRT. PTV_D2% remained largely unchanged, and HI/CI deteriorated only slightly. OAR dose variations were minimal, with no significant differences except for a lower Breast_Dmean in the IMRT plan. Respiratory motion showed no meaningful correlations with most dosimetric parameters, except for weak correlations between liver motion and PTV_V95% and a significant correlation with Breast_Dmean in the IMRT plan.
conclusionsIn this cohort, chest wall motion amplitude after breathing training remained within 3.1 mm. Under these conditions, Hybrid and IMRT plans demonstrate comparable target dose robustness, while Hybrid achieves superior OAR sparing, particularly in the low-dose region. Based on this comparison, Hybrid planning may be considered a favorable option relative to IMRT for hypofractionated whole-breast irradiation under free breathing.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.