Evidence map›Paper›PMID 41803814›Full record

ArticleBMC oral health2026

Clinical and radiographic outcomes of a novel posterior occlusal splint in adults with temporomandibular joint osteoarthritis: a retrospective case series.

Zhenlong Liu, Junxi Feng, Liwen Huang, Yunyi Yuan, Rong Zhang, Xingyang Li, Qingbin Zhang, Antong Wu, Wei Cao

Abstract read
In one paragraph

Article in BMC oral health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zhenlong Liu *Department of Temporomandibular Joint, School and Hospital of Stomatology, Guangdong Engineering Research Center of Oral Restoration and Reconstruction, Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou Medical University, Dongfengxi Road 195, Guangzhou, 510180, China.
Junxi Feng *Department of Temporomandibular Joint, School and Hospital of Stomatology, Guangdong Engineering Research Center of Oral Restoration and Reconstruction, Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou Medical University, Dongfengxi Road 195, Guangzhou, 510180, China.
Liwen Huang *Department of Temporomandibular Joint, School and Hospital of Stomatology, Guangdong Engineering Research Center of Oral Restoration and Reconstruction, Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou Medical University, Dongfengxi Road 195, Guangzhou, 510180, China.
Yunyi YuanOrthodontics and Pediatric Dentistry Center, School and Hospital of Stomatology, Guangdong Engineering Research Center of Oral Restoration and Reconstruction, Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou Medical University, Guangzhou, China.
Rong ZhangDepartment of Temporomandibular Joint, School and Hospital of Stomatology, Guangdong Engineering Research Center of Oral Restoration and Reconstruction, Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou Medical University, Dongfengxi Road 195, Guangzhou, 510180, China.
Xingyang LiDepartment of Temporomandibular Joint, School and Hospital of Stomatology, Guangdong Engineering Research Center of Oral Restoration and Reconstruction, Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou Medical University, Dongfengxi Road 195, Guangzhou, 510180, China.
Qingbin ZhangDepartment of Temporomandibular Joint, School and Hospital of Stomatology, Guangdong Engineering Research Center of Oral Restoration and Reconstruction, Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou Medical University, Dongfengxi Road 195, Guangzhou, 510180, China.
Antong Wu *Department of Temporomandibular Joint, School and Hospital of Stomatology, Guangdong Engineering Research Center of Oral Restoration and Reconstruction, Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou Medical University, Dongfengxi Road 195, Guangzhou, 510180, China. antongwu@gzhmu.edu.cn.
Wei Cao *Department of Temporomandibular Joint, School and Hospital of Stomatology, Guangdong Engineering Research Center of Oral Restoration and Reconstruction, Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou Medical University, Dongfengxi Road 195, Guangzhou, 510180, China. doctor.cao@gzhmu.edu.cn.

Funding

National Key Research and Development Program of China 2023YFC2509200National Natural Science Foundation of China 82370985
6 · The paper itself

Abstract

objectiveTo describe the clinical and radiographic outcomes associated with the use of a novel posterior occlusal splint (nPOS) in adults with temporomandibular joint osteoarthritis (TMJ-OA) and its impact on condylar morphology, as assessed by cone-beam computed tomography (CBCT). METHODS AND MATERIALS: This retrospective study included 156 adult patients (24 males, 132 females; mean age: 27.05 ± 9.18 years) diagnosed with TMJ-OA, with 182 osteoarthritis (OA)-like condyles. All patients received treatment with the nPOS between January 2020 and December 2024. Clinical symptoms were evaluated at six time points: T0 (baseline), T1 (1 month), T2 (3 months), T3 (6 months), T4 (12 months), and T5 (24 months) after treatment initiation. CBCT assessments of condylar morphology were performed at T0, T3, T4, and T5. Wilcoxon signed-rank test, paired t test, McNemar test were employed to evaluate longitudinal changes in clinical symptoms.

resultsSignificant improvements in maximum mouth opening (MMO) were observed from T2 to T4 (P < 0.01). Significant reductions in spontaneous pain were observed at both T3 and T4 (P < 0.01), while reductions in joint tenderness and joint noises were statistically confirmed at T3 (P < 0.01). No significant changes were noted for intermittent closed lock (ICL), muscle pain, push-back mandibular test, or altered mouth opening patterns (P > 0.01). CBCT showed a significant improvement in condylar cortical score at T3 compared to T0 (P < 0.01).

conclusionIn this observational study, the use of nPOS was associated with improvements in key TMJ-OA symptoms and condylar morphology, especially during the early to mid-treatment phase (3-12 months). These findings warrant validation in randomized controlled trials before clinical adoption. Furthermore, long-term effects require further investigation.

Indexed as

Occlusal SplintsOsteoarthritisTemporomandibular Joint DisordersAdultCone-Beam Computed TomographyFemaleHumansMaleMandibular CondyleRetrospective StudiesTreatment OutcomeCone-beam computed tomographyOcclusal splintTemporomandibular disordersTemporomandibular joint osteoarthritis

Identifiers

PMID41803814
PMCPMC13085602

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.