Evidence map›Paper›PMID 41803790›Full record

ArticleBMC infectious diseases2026

Positivity rate of Aspergillus spp. in patients with tuberculosis-like symptoms in Yaoundé, Cameroon and antifungal resistance profile.

Solange Meyin A Ebong, Vigny Ndé Kengne, Moïse Ntah A Ayong, Loick Pradel Kojom Foko, Juliette Lauryn Nga Ambono, Ghislaine Metsina Ndzana, Mélanie Togonodji Baïdam, Oben Youguitcha, Olivier Ziem A Abah, Célestin Ayangma and 1 more

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Article in BMC infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

11 authors.

Solange Meyin A EbongDepartment of Microbiology, Faculty of Science, University of Yaoundé I, P.O. Box 812, Yaoundé, Cameroon. ebongsolange@yahoo.fr.ORCID http://orcid.org/0000-0002-3184-2396
Vigny Ndé KengneDepartment of Microbiology, Faculty of Science, University of Yaoundé I, P.O. Box 812, Yaoundé, Cameroon.
Moïse Ntah A AyongDepartment of Biochemistry, Faculty of Science, University of Douala, P.O. Box 24157, Douala, Cameroon.
Loick Pradel Kojom FokoDepartment of Biochemistry, Faculty of Science, University of Douala, P.O. Box 24157, Douala, Cameroon.
Juliette Lauryn Nga AmbonoDepartment of Microbiology, Faculty of Science, University of Yaoundé I, P.O. Box 812, Yaoundé, Cameroon.
Ghislaine Metsina NdzanaDepartment of Microbiology, Faculty of Science, University of Yaoundé I, P.O. Box 812, Yaoundé, Cameroon.
Mélanie Togonodji BaïdamDepartment of Microbiology, Faculty of Science, University of Yaoundé I, P.O. Box 812, Yaoundé, Cameroon.
Oben YouguitchaDepartment of Biochemistry, Faculty of Science, University of Douala, P.O. Box 24157, Douala, Cameroon.
Olivier Ziem A AbahDepartment of Microbiology, Faculty of Science, University of Yaoundé I, P.O. Box 812, Yaoundé, Cameroon.
Célestin AyangmaDepartment of Bacteriology, Yaoundé No 1 Regional Military Hospital, P.O Box 1218 , Yaoundé, Cameroon.
Francioli Koro KoroDepartment of Biochemistry, Faculty of Science, University of Douala, P.O. Box 24157, Douala, Cameroon.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPulmonary aspergillosis represents a significant public health concern resulting from the proliferation of Aspergillus species within the respiratory tract. This infection is frequently underdiagnosed in comparison to tuberculosis during the management of pulmonary infections, especially among individuals living with HIV. The objective of this study was to determine the positivity rate of Aspergillus spp. from sputum and bronchoalveolar lavage (BAL) samples of patients presenting with tuberculosis-like symptoms at Jamot Hospital in Yaoundé, Cameroon, and to evaluate their antifungal resistance profiles.

methodsA total of 114 samples (104 sputum and 10 bronchoalveolar lavage) were collected for mycological analysis. Data were verified, coded, and analyzed using StatView v5.0 and GraphPad v8.0.2 for Windows. Pearson's chi-square test of independence and multivariate logistic regression models were used to compare percentages, with p < 0.05 considered statistically significant.

resultsAspergillus spp. were detected in 12.3% of samples, with two species identified. Aspergillus niger was predominant (57%0), followed by Aspergillus flavus (29%). A. niger isolates tested (5) exhibited resistance to polyenes, with 80% resistant to amphotericin B and 40% to nystatin, and 20% resistant to the azole fluconazole. All A. niger isolates were susceptible to econazole and clotrimazole. Among the five A. flavus isolates tested, all demonstrated resistance to amphotericin B and fluconazole, 60% to nystatin, and 20% to clotrimazole.

conclusionAspergillus spp. is present in the respiratory tract but often overlooked, and can lead to a misdiagnosis of tuberculosis. Although the very small number of isolates tested, Aspergillus spp. could be also affected to the antimicrobial resistance observed in recent years.

Indexed as

Antifungal AgentsAspergillusPulmonary AspergillosisTuberculosis, PulmonaryAdultAgedAged, 80 and overBronchoalveolar Lavage FluidCameroonCross-Sectional StudiesDiagnosis, DifferentialDiagnostic ErrorsDrug Resistance, FungalFemaleHumansMaleAntifungal AgentsAntifungal resistanceJamot hospital of YaoundéPositivity rate of Aspergillus spp.Tuberculosis-like symptoms

Identifiers

PMID41803790
PMCPMC13085512

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.