ArticleBMC neurology2026
Associations of hs-CRP and D-Dimer with stroke severity and early functional outcomes in ischemic stroke: a retrospective age-stratified cohort study.
Article in BMC neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Association of C-Reactive Protein with Functional Outcome After Acute Ischemic Stroke Across TOAST Subtypes.Journal of clinical medicine · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
backgroundInflammatory and coagulation pathways contribute to the pathophysiology of acute ischemic stroke. High sensitivity C reactive protein and D Dimer are routinely measured biomarkers; however, their clinical relevance for early stroke severity and functional outcome, particularly across age groups, remains incompletely defined.
methodsThis retrospective cohort study included 622 patients with imaging confirmed acute ischemic stroke admitted between January 2023 and June 2025. Admission National Institutes of Health Stroke Scale scores, vascular risk factors, and laboratory biomarkers including hs CRP and D Dimer were collected within twenty four hours of admission. Functional outcome at discharge was assessed using the modified Rankin Scale and dichotomized as good (≤ 2) or poor (> 2). Associations between biomarkers, stroke severity, and outcome were evaluated using correlation analyses and multivariable logistic regression. Age stratified analyses were performed as a secondary objective.
resultsThe median admission NIHSS score was 2 (interquartile range 1–5). hs CRP levels were positively correlated with NIHSS scores (Spearman rho 0.21, p < 0.001), as were D Dimer levels (Spearman rho 0.16, p < 0.001). Patients with poor functional outcome had higher admission hs CRP levels (p = 0.004) and higher NIHSS scores (p < 0.001). In multivariable analysis, higher NIHSS score (odds ratio 1.32, 95% confidence interval 1.18–1.48) and hypertension (odds ratio 2.11, 95% confidence interval 1.19–3.72) were independently associated with poor outcome, while hs CRP showed a borderline association and D Dimer was not independently associated after adjustment. Associations between biomarkers and stroke severity were consistent across age groups.
conclusionsAdmission hs CRP and D Dimer levels are modestly associated with initial stroke severity in acute ischemic stroke, while elevated hs CRP is associated with poor early functional outcome at hospital discharge. These associations appear largely mediated by stroke severity. Stroke severity and hypertension remain the strongest predictors of early recovery. Inflammatory biomarkers may provide adjunctive information for early risk stratification when interpreted alongside established clinical assessments.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.