Evidence map›Paper›PMID 41803737›Full record

ArticleBMC cancer2026

Amino acid metabolism-related genes signature correlates with immune infiltration and predicts clinic prognosis in osteosarcoma.

Deshuang Xi, Yilin Teng, Shaobo Wang, Meng Zhang, Gang Liu, Bo Han, Yunpeng Zhang, Xiao Tian, Chunxin Cheng, Shouguo Wang and 2 more

Abstract read
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In one paragraph

Article in BMC cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Deshuang XiDepartment of Orthopedics, Huai'an First People's Hospital, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huai'an, 223300, China.
Yilin TengDepartment of Spine and Osteopathic Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, China.
Shaobo WangDepartment of Orthopedics, Huai'an First People's Hospital, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huai'an, 223300, China.
Meng ZhangDepartment of Orthopedics, Huai'an First People's Hospital, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huai'an, 223300, China.
Gang LiuDepartment of Orthopedics, Huai'an First People's Hospital, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huai'an, 223300, China.
Bo HanDepartment of Orthopedics, Huai'an First People's Hospital, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huai'an, 223300, China.
Yunpeng ZhangDepartment of Orthopedics, Huai'an First People's Hospital, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huai'an, 223300, China.
Xiao TianDepartment of Orthopedics, Huai'an First People's Hospital, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huai'an, 223300, China.
Chunxin ChengDepartment of Orthopedics, Huai'an First People's Hospital, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huai'an, 223300, China.
Shouguo WangDepartment of Orthopedics, Huai'an First People's Hospital, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huai'an, 223300, China.
Weidong LiuDepartment of Orthopedics, Huai'an First People's Hospital, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huai'an, 223300, China. lwdhayy@126.com.
Peng SunDepartment of Orthopedics, Huai'an First People's Hospital, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huai'an, 223300, China. sunpeng881203@126.com.

Funding

Huai'an Natural Science Research Program HABL202233
6 · The paper itself

Abstract

backgroundAmino acid metabolism is crucial for tumor cell proliferation and survival. However, its role in osteosarcoma (OS) remains incompletely characterized. The current study aimed to investigate the role of the amino acid metabolism-associated risk signature in prognostication and immune cell infiltration in osteosarcoma.

methodsThe clinical and transcriptome data of patients with OS were retrieved using the TARGET and GEO databases. Consensus clustering of amino acid metabolism-related genes (AAMRGs) stratified the osteosarcoma patients. Least absolute shrinkage and selection operator regression and Cox analysis were performed to build prognostic models. The expression levels of genes comprising the risk model were validated in vitro. Subsequently, the model was validated in an external cohort.

resultsThe risk model developed using five AAMRGs demonstrated appreciable ability to predict overall survival in osteosarcoma patients compared to traditional clinical factors. qPCR validated expression of the five AAMRGs comprising the risk model. Single-cell RNA sequencing and drug prediction analyses extend understanding of modeling AAMRGs in OS.

conclusionThe current prognostic signature utilizing five AAMRGs can accurately predict prognosis in osteosarcoma and may provide new insights into amino acid metabolism in OS.

Indexed as

Amino AcidsBiomarkers, TumorBone NeoplasmsOsteosarcomaFemaleGene Expression ProfilingGene Expression Regulation, NeoplasticHumansMalePrognosisTranscriptomeTumor MicroenvironmentAmino AcidsBiomarkers, TumorAmino acid metabolismOsteosarcomaPrognostic signatureTumor immune microenvironment

Identifiers

PMID41803737
PMCPMC13097926

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