Evidence map›Paper›PMID 41803732›Full record

ReviewBMC medical research methodology2026

Artificial intelligence and machine learning in non-small cell lung cancer: the current state of the science on multi-omic applications.

Savy Nistala, Julius Niyonzima, Raunak Chahal, Alina Hasan, Evelyn Ho, Arielle Janssens, Leroy W Wheeler, Mark Nichols, Saman Zeeshan

Abstract readReview
In one paragraph

Review in BMC medical research methodology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Savy NistalaSchool of Medicine, The University of Missouri-Kansas City, Kansas City, MO, 64108, USA.
Julius NiyonzimaDepartment of Computer Sciences, School of Science and Engineering, The University of Missouri-Kansas City, Kansas City, MO, 64110, USA.
Raunak ChahalSchool of Medicine, The University of Missouri-Kansas City, Kansas City, MO, 64108, USA.
Alina HasanDepartment of Applied Mathematics and Statistics, Whiting School of Engineering, Johns Hopkins University, Baltimore, MD, 21218, USA.
Evelyn HoDepartment of Biological Sciences, School of Science and Engineering, The University of Missouri-Kansas City, Kansas City, MO, 64110, USA.
Arielle JanssensDepartment of Chemical and Biomedical Engineering, College of Engineering, The University of Missouri-Columbia, Columbia, MO, 65211, USA.
Leroy W WheelerDepartment of Biomedical and Health Informatics, School of Medicine, The University of Missouri-Kansas City, Kansas City, MO, 64108, USA.
Mark NicholsDepartment of Biomedical and Health Informatics, School of Medicine, The University of Missouri-Kansas City, Kansas City, MO, 64108, USA.
Saman ZeeshanDepartment of Biomedical and Health Informatics, School of Medicine, The University of Missouri-Kansas City, Kansas City, MO, 64108, USA. saman.zeeshan@umkc.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Non-small cell lung cancer (NSCLC) accounts for the majority of lung cancer cases and remains a leading cause of cancer-related mortality globally. The biological heterogeneity of NSCLC challenges early detection, accurate staging, and optimal therapy. Recent advances in artificial intelligence (AI) and machine learning (ML) have enabled the integration of high-dimensional clinical, genomic, and imaging data, transforming cancer care. This narrative review critically examines recent AI/ML applications in NSCLC, emphasizing clinical validation, interpretability, and ethical deployment. We synthesize data from leading studies on imaging, genomics, and multimodal integration, highlighting how deep learning and ensemble methods have begun to outperform traditional diagnostic workflows. Persistent challenges, including dataset diversity, lack of external validation, interpretability, and ethical considerations must be addressed to realize translational impact. We advocate for large-scale, interdisciplinary collaboration to advance AI-powered personalized medicine and improve patient outcomes in NSCLC.

Indexed as

Artificial IntelligenceCarcinoma, Non-Small-Cell LungLung NeoplasmsMachine LearningGenomicsHumansMultiomicsPrecision MedicineSoft ComputingArtificial IntelligenceDeep LearningDiagnosisEnsemble ModelsGenomicsImagingMachine LearningNSCLCPrognosisRisk Factors

Identifiers

PMID41803732
PMCPMC13085305

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.