Evidence map›Paper›PMID 41803604›Full record

ArticleMikrochimica acta2026

Biofunctional alginate hydrogel enabling Fe³⁺ detection and therapeutic modulation of hepatic fibrosis.

Jiaxing Li, Qiao Li, Zhongqi Huang, Yongsong Huang, Rongqi Wang, Jiazhu Wei, Ze Wang, Junxia Pu, Chengtong Liu, Wujun Wei

Abstract read
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In one paragraph

Article in Mikrochimica acta, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Jiaxing Li *Department of pharmacy, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, Guangxi, China.
Qiao Li *Department of Neurology, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, Guangxi, China.
Zhongqi HuangDepartment of Pediatric Health and Rehabilitation, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, Guangxi, China.
Yongsong HuangCenter for Clinical Laboratory Diagnosis and Research, Key Laboratory of Research and Development on Clinical Molecular Diagnosis for High-Incidence Diseases of Baise, Key Laboratory of Research on Clinical Molecular Diagnosis for High Incidence Diseases in Western Guangxi of Guangxi Higher Education Institutions, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, Guangxi, China.
Rongqi WangCenter for Clinical Laboratory Diagnosis and Research, Key Laboratory of Research and Development on Clinical Molecular Diagnosis for High-Incidence Diseases of Baise, Key Laboratory of Research on Clinical Molecular Diagnosis for High Incidence Diseases in Western Guangxi of Guangxi Higher Education Institutions, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, Guangxi, China.
Jiazhu WeiCenter for Clinical Laboratory Diagnosis and Research, Key Laboratory of Research and Development on Clinical Molecular Diagnosis for High-Incidence Diseases of Baise, Key Laboratory of Research on Clinical Molecular Diagnosis for High Incidence Diseases in Western Guangxi of Guangxi Higher Education Institutions, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, Guangxi, China.
Ze WangCenter for Clinical Laboratory Diagnosis and Research, Key Laboratory of Research and Development on Clinical Molecular Diagnosis for High-Incidence Diseases of Baise, Key Laboratory of Research on Clinical Molecular Diagnosis for High Incidence Diseases in Western Guangxi of Guangxi Higher Education Institutions, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, Guangxi, China.
Junxia PuCenter for Clinical Laboratory Diagnosis and Research, Key Laboratory of Research and Development on Clinical Molecular Diagnosis for High-Incidence Diseases of Baise, Key Laboratory of Research on Clinical Molecular Diagnosis for High Incidence Diseases in Western Guangxi of Guangxi Higher Education Institutions, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, Guangxi, China.
Chengtong LiuDepartment of pharmacy, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, Guangxi, China. yyfylct@163.com.
Wujun WeiCenter for Clinical Laboratory Diagnosis and Research, Key Laboratory of Research and Development on Clinical Molecular Diagnosis for High-Incidence Diseases of Baise, Key Laboratory of Research on Clinical Molecular Diagnosis for High Incidence Diseases in Western Guangxi of Guangxi Higher Education Institutions, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, Guangxi, China. wjw416413@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hepatic fibrosis, driven by hepatic stellate cell (HSC) activation and excessive extracellular matrix (ECM) deposition, is closely associated with iron overload. To enable simultaneous diagnosis and treatment, a multifunctional hydrogel nanocomposite (SA-1@MG) was developed by modifying sodium alginate with a compound 1-based Fe³⁺-responsive fluorophore and loading mangiferin (MG). SA-1@MG exhibited strong, selective fluorescence quenching toward Fe³⁺ (R² = 0.9992) and high stability under physiological conditions. In vitro studies using TGF-β1-induced LX-2 cells confirmed that SA-1@MG effectively suppressed fibrotic markers (ACTA2, COL1A1, TIMP1, TGFB1), demonstrating enhanced antifibrotic activity compared to free MG. These results highlight SA-1@MG as a dual-functional platform for Fe³⁺ fluorescence detection and hepatic fibrosis therapy, providing a promising strategy for early diagnosis and treatment of liver fibrosis.

Indexed as

AlginatesHydrogelsIronLiver CirrhosisCell LineFluorescent Chemosensor CompoundsFluorescent DyesGlucuronic AcidHepatic Stellate CellsHexuronic AcidsHumansNanocompositesTransforming Growth Factor beta1XanthonesAlginatesFluorescent Chemosensor CompoundsFluorescent DyesGlucuronic AcidHexuronic AcidsHydrogelsIronmangiferinTransforming Growth Factor beta1XanthonesECMFluorescenceHSCMultifunctional hydrogel nanocomposite

Identifiers

PMID41803604

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