Evidence map›Paper›PMID 41803570›Full record

ArticleJournal of molecular histology2026

Adipose-derived stem cell exosomes promote endometrial carcinoma progression via MAGED4B/CDH1/EMT axis.

Yifen Li, Gangwei Wang, Jianwei Chen, Tao Xu, Xiaomao Li, Yuebo Yang, Yu Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of molecular histology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yifen Li *Gynecology Department of the Third Affiliated Hospital, Sun Yat sen University, No. 600 Tianhe Road, Tianhe District, Guangzhou, 510630, Guangdong, China.
Gangwei Wang *Emergency Department of the Third Affiliated Hospital, Sun Yat sen University, Guangzhou, Guangdong, China.
Jianwei ChenPrecision Medicine and Healthcare Research Center, Tsinghua-Berkeley Shenzhen Institute (TBSI), Tsinghua University, Shenzhen, Guangdong, China.
Tao XuPrecision Medicine and Healthcare Research Center, Tsinghua-Berkeley Shenzhen Institute (TBSI), Tsinghua University, Shenzhen, Guangdong, China.
Xiaomao LiGynecology Department of the Third Affiliated Hospital, Sun Yat sen University, No. 600 Tianhe Road, Tianhe District, Guangzhou, 510630, Guangdong, China.
Yuebo YangGynecology Department of the Third Affiliated Hospital, Sun Yat sen University, No. 600 Tianhe Road, Tianhe District, Guangzhou, 510630, Guangdong, China. yangyueb@mail.sysu.edu.cn.
Yu ZhangGynecology Department of the Third Affiliated Hospital, Sun Yat sen University, No. 600 Tianhe Road, Tianhe District, Guangzhou, 510630, Guangdong, China. zhangyu6@mail.sysu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adipose-derived stem cell exosomes (ADSCs-Exos) enhance endometrial carcinoma (EC) cell proliferation, migration, and invasion. Mechanistically, ADSCs-Exos downregulate MAGED4B and CDH1, reduce E-cadherin expression, and upregulate vimentin, promoting epithelial-mesenchymal transition (EMT). Overexpression of MAGED4B reverses these effects and inhibits malignant behaviors. Furthermore, ADSCs-Exos increase organoid viability and confirm key protein changes. These findings demonstrate that ADSCs-Exos promote EC progression via the MAGED4B/CDH1/EMT axis.

Indexed as

Adipose TissueCadherinsEndometrial NeoplasmsEpithelial-Mesenchymal TransitionExosomesMesenchymal Stem CellsNeoplasm ProteinsAnimalsCell Line, TumorCell MovementCell ProliferationDisease ProgressionFemaleHumansCadherinsNeoplasm ProteinsAdipose derived mesenchymal stem cellsCDH1E-cadherinEMTEndometrial carcinomaExosomesMAGED4BOrganoidSMAD4

Identifiers

PMID41803570
PMCPMC12971778

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.